1-acetyl-5,7-diacetamido-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine

Base Information

• Chemical Name: 1-acetyl-5,7-diacetamido-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine
• CAS No.: 121596-27-8
• Molecular Formula: C₂₀H₂₁N₅O₃
• Molecular Weight: 379.418
• Mol file: 121596-27-8.mol

Synonyms:1-acetyl-5,7-diacetamido-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine

Chemical Property of 1-acetyl-5,7-diacetamido-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-acetyl-5,7-diacetamido-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine

There total 5 articles about 1-acetyl-5,7-diacetamido-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

acetic anhydride (108-24-7) + 5,7-diamino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine (121572-50-7) → 1-acetyl-5,7-diacetamido-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine (121596-27-8)

Guidance literature:

at 65 ℃; for 1.5h;

DOI:10.1021/jm00130a023

Reference yield:

2,6-diamino-4-chloro-3-nitropyridine (40497-64-1) → 1-acetyl-5,7-diacetamido-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine (121596-27-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 51 percent / Et₃N, N,N-dimethylacetamide / ethanol / 1.2 h / Heating

2: 60 percent / H₂ / Raney-Ni / N,N-dimethyl-acetamide / 24 h

3: 7 percent / 1.5 h / 65 °C

With N,N-dimethyl acetamide; hydrogen; triethylamine; nickel; In ethanol; N,N-dimethyl acetamide;

DOI:10.1021/jm00130a023

Reference yield:

ethyl 6-amino-4-<(1-methyl-2-oxo-2-phenylethyl)amino>-5-nitro-2-pyridinecarbamate oxime (83269-20-9) → 1-acetyl-5,7-diacetamido-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine (121596-27-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / H₂NNH₂ / Ambient temperature

2: 60 percent / H₂ / Raney-Ni / N,N-dimethyl-acetamide / 24 h

3: 7 percent / 1.5 h / 65 °C

With hydrogen; hydrazine; nickel; In N,N-dimethyl acetamide;

DOI:10.1021/jm00130a023

upstream raw materials:

acetic anhydride

5,7-diamino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine

2,6-diamino-4-chloro-3-nitropyridine

α-aminopropiophenone oxime