2,4-dichloro-N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-1,2,3,4-tetrahydro-isoquinolin-7-yloxy}-ethyl)-benzamide

Base Information

Chemical Name:2,4-dichloro-N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-1,2,3,4-tetrahydro-isoquinolin-7-yloxy}-ethyl)-benzamide
CAS No.:1190772-11-2
Molecular Formula:C₂₈H₂₇Cl₃N₂O₂
Molecular Weight:529.894
Hs Code.:

Synonyms:2,4-dichloro-N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-1,2,3,4-tetrahydro-isoquinolin-7-yloxy}-ethyl)-benzamide

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Chemical Property of 2,4-dichloro-N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-1,2,3,4-tetrahydro-isoquinolin-7-yloxy}-ethyl)-benzamide

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Technology Process of 2,4-dichloro-N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-1,2,3,4-tetrahydro-isoquinolin-7-yloxy}-ethyl)-benzamide

There total 8 articles about 2,4-dichloro-N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-1,2,3,4-tetrahydro-isoquinolin-7-yloxy}-ethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1190643-35-6
2,4-dichloro-N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-ethyl)-benzamide

: 1190772-11-2
2,4-dichloro-N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-1,2,3,4-tetrahydro-isoquinolin-7-yloxy}-ethyl)-benzamide

Guidance literature:: With sodium tetrahydroborate; In methanol; water; at 20 ℃; for 14h;

Reference yield:

: 50921-39-6
1-(4-chlorophenyl)cyclobutane-1-carboxylic acid

: 1190772-11-2
2,4-dichloro-N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-1,2,3,4-tetrahydro-isoquinolin-7-yloxy}-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 - 20 °C

2.1: trichlorophosphate / toluene / 8 h / Reflux

3.1: water; hydrogen bromide / 4 h / 120 °C

3.2: pH 10

4.1: sodium hydride / N,N-dimethyl acetamide / 20 °C

5.1: hydrogenchloride / dichloromethane; isopropyl alcohol / 14 h

6.1: triethylamine / dichloromethane / 14 h / 20 °C

7.1: sodium tetrahydroborate / methanol; water / 14 h / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; water; hydrogen bromide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl acetamide; water; isopropyl alcohol; toluene;

Reference yield:

: 916923-23-4
1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]cyclobutanecarboxamide

: 1190772-11-2
2,4-dichloro-N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-1,2,3,4-tetrahydro-isoquinolin-7-yloxy}-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / toluene / 8 h / Reflux

2.1: water; hydrogen bromide / 4 h / 120 °C

2.2: pH 10

3.1: sodium hydride / N,N-dimethyl acetamide / 20 °C

4.1: hydrogenchloride / dichloromethane; isopropyl alcohol / 14 h

5.1: triethylamine / dichloromethane / 14 h / 20 °C

6.1: sodium tetrahydroborate / methanol; water / 14 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; water; hydrogen bromide; sodium hydride; triethylamine; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl acetamide; water; isopropyl alcohol; toluene;