2-oxo-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:2-oxo-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide
CAS No.:1428155-51-4
Molecular Formula:C₂₉H₂₃F₃N₆O₃
Molecular Weight:560.535
Hs Code.:

Synonyms:2-oxo-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-oxo-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-oxo-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

There total 8 articles about 2-oxo-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1428155-00-3
2-oxo-1-(4-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylic acid

: 1428155-06-9
3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)aniline

: 1428155-51-4
2-oxo-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 7306-68-5
6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1428155-51-4
2-oxo-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 15 h / 100 °C / Inert atmosphere; Sealed tube

2: ammonium chloride; iron / water; ethanol / 2 h / 90 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; ethanol; dichloromethane; water; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 609-71-2
2-hydroxy-3-carboxypyridine

: 1428155-51-4
2-oxo-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)-1-(4-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / dichloromethane / 4 h / 75 °C

2.1: 12 h / 20 °C

3.1: ethyl 2-oxocyclohexane carboxylate; caesium carbonate; copper(I) bromide / dimethyl sulfoxide / 18 h / 60 °C / Sealed tube

4.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

4.2: pH 2 - 3

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With thionyl chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; ethyl 2-oxocyclohexane carboxylate; HATU; copper(I) bromide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2012.06.005