1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)urea

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Chemical Name:1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)urea
CAS No.:1350454-76-0
Molecular Formula:C₂₇H₂₁F₆N₇O₂S
Molecular Weight:621.566
Hs Code.:

Synonyms:1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)urea

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Chemical Property of 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)urea

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Technology Process of 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)urea

There total 6 articles about 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.3%

: 6-(3-methoxyphenyl)-5-(2-(methylsulfonyl)pyrimidin-4-yl)imidazo[2,1-b]thiazole

: 1360816-01-8
1-(2-aminoethyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea

: 1350454-76-0
1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)urea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 80 ℃; for 8h;
DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

: 815596-13-5
6-(3-Methoxyphenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole

: 1350454-76-0
1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: Oxone / methanol; water / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

With Oxone; N-ethyl-N,N-diisopropylamine; In methanol; water; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

: C₁₉H₁₇F₆N₃O₃

: 1350454-76-0
1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.024