(4R,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole

Base Information

• Chemical Name: (4R,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole
• CAS No.: 131065-69-5
• Molecular Formula: C₁₈H₁₉NO₅S
• Molecular Weight: 361.419
• Mol file: 131065-69-5.mol

Synonyms:(4R,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole

Chemical Property of (4R,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole

There total 3 articles about (4R,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + 3,4-dimethoxy-benzaldehyde (120-14-9) → (4S,5S)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole (131065-69-5) + (4R,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole (131065-69-5) + (4S,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole (131065-69-5)

Guidance literature:

silver triflate-chiral ligand 1a; In dichloromethane; at 25 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00311a007

Reference yield:

[(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + 3,4-dimethoxy-benzaldehyde (120-14-9) → (4S,5S)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole (131065-69-5) + (4R,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole (131065-69-5) + (4S,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole (131065-69-5)

Guidance literature:

silver triflate-chiral ligand 1a; In dichloromethane; at 25 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00311a007

Reference yield:

[(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + 3,4-dimethoxy-benzaldehyde (120-14-9) → (4S,5S)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole (131065-69-5) + (4R,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole (131065-69-5) + (4S,5R)-5-(3,4-Dimethoxy-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole (131065-69-5)

Guidance literature:

silver triflate-chiral ligand 1a; In dichloromethane; at 25 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00311a007

upstream raw materials:

[(p-methylphenyl)sulfonylmethyl]isonitrile

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

(R)-1-(3,4-Dimethoxy-phenyl)-2-methylamino-ethanol