6-(difluoromethoxy)-5-((2-(4-((4-hydroxypiperidin-1-yl)methyl)benzamide)pyridin-4-yl)oxy)-N-methyl-1H-indole-1-carboxamide

Base Information

Chemical Name:6-(difluoromethoxy)-5-((2-(4-((4-hydroxypiperidin-1-yl)methyl)benzamide)pyridin-4-yl)oxy)-N-methyl-1H-indole-1-carboxamide
CAS No.:1622204-18-5
Molecular Formula:C₂₉H₂₉F₂N₅O₅
Molecular Weight:565.577
Hs Code.:

Synonyms:6-(difluoromethoxy)-5-((2-(4-((4-hydroxypiperidin-1-yl)methyl)benzamide)pyridin-4-yl)oxy)-N-methyl-1H-indole-1-carboxamide

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Chemical Property of 6-(difluoromethoxy)-5-((2-(4-((4-hydroxypiperidin-1-yl)methyl)benzamide)pyridin-4-yl)oxy)-N-methyl-1H-indole-1-carboxamide

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Technology Process of 6-(difluoromethoxy)-5-((2-(4-((4-hydroxypiperidin-1-yl)methyl)benzamide)pyridin-4-yl)oxy)-N-methyl-1H-indole-1-carboxamide

There total 12 articles about 6-(difluoromethoxy)-5-((2-(4-((4-hydroxypiperidin-1-yl)methyl)benzamide)pyridin-4-yl)oxy)-N-methyl-1H-indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1622205-49-5
C₂₄H₁₉ClF₂N₄O₄

: 1622204-18-5
6-(difluoromethoxy)-5-((2-(4-((4-hydroxypiperidin-1-yl)methyl)benzamide)pyridin-4-yl)oxy)-N-methyl-1H-indole-1-carboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 14h; Inert atmosphere;

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1622204-18-5
6-(difluoromethoxy)-5-((2-(4-((4-hydroxypiperidin-1-yl)methyl)benzamide)pyridin-4-yl)oxy)-N-methyl-1H-indole-1-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide / water; N,N-dimethyl-formamide / 2 h / 120 °C

2.1: potassium carbonate / acetonitrile / 3 h / 20 °C

3.1: acetic acid; ammonium acetate / 3 h / 130 °C / Inert atmosphere

4.1: acetic acid; nitric acid / dichloromethane / 3.92 h / 75 °C / Cooling with ice

4.2: 1 h / 70 °C / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / water; ethanol / 1.25 h / 20 °C

6.1: acetic acid; potassium tert-butylate / dimethyl sulfoxide / 1.33 h / 160 °C / Inert atmosphere

7.1: methanol; sodium methylate / 3.5 h / 65 °C / Inert atmosphere

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

8.2: 0.83 h / 0 - 20 °C / Inert atmosphere

9.1: triethylamine / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

10.1: N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere

With methanol; palladium 10% on activated carbon; potassium tert-butylate; ammonium acetate; hydrogen; nitric acid; sodium methylate; sodium hydride; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1622205-55-3
5-((2-aminopyridin-4-yl)oxy)-6-(difluoromethoxy)-N-methyl-1H-indole-1-carboxamide

: 1622204-18-5
6-(difluoromethoxy)-5-((2-(4-((4-hydroxypiperidin-1-yl)methyl)benzamide)pyridin-4-yl)oxy)-N-methyl-1H-indole-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;