β-benzyl N-phosphonoacetyl-L-isoasparaginate

Base Information

• Chemical Name: β-benzyl N-phosphonoacetyl-L-isoasparaginate
• CAS No.: 913094-95-8
• Molecular Formula: C₁₃H₁₇N₂O₇P
• Molecular Weight: 344.261
• Mol file: 913094-95-8.mol

Synonyms:β-benzyl N-phosphonoacetyl-L-isoasparaginate

Chemical Property of β-benzyl N-phosphonoacetyl-L-isoasparaginate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of β-benzyl N-phosphonoacetyl-L-isoasparaginate

There total 6 articles about β-benzyl N-phosphonoacetyl-L-isoasparaginate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

β-benzyl N-(diethoxyphosphinoyl)acetyl-L-isoasparaginate (913094-94-7) → β-benzyl N-phosphonoacetyl-L-isoasparaginate (913094-95-8)

Guidance literature:

β-benzyl N-(diethoxyphosphinoyl)acetyl-L-isoasparaginate; With trimethylsilyl bromide; In acetonitrile; at 20 ℃;

With water; at 20 ℃; for 1h;

DOI:10.1021/jm0607294

Reference yield:

β-benzyl N-chloroacetyl-L-isoasparaginate (913094-93-6) → β-benzyl N-phosphonoacetyl-L-isoasparaginate (913094-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 95 percent / 8 h / 150 °C

2.1: trimethylsilyl bromide / acetonitrile / 20 °C

2.2: 100 percent / H₂O / 1 h / 20 °C

With trimethylsilyl bromide; In acetonitrile;

DOI:10.1021/jm0607294

Reference yield:

N-t-butyloxycarbonyl-L-aspartic acid β-benzyl ester α-amide (87421-27-0) → β-benzyl N-phosphonoacetyl-L-isoasparaginate (913094-95-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / CH₂Cl₂ / 4 h / 20 °C

2.1: 80 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

3.1: 95 percent / 8 h / 150 °C

4.1: trimethylsilyl bromide / acetonitrile / 20 °C

4.2: 100 percent / H₂O / 1 h / 20 °C

With pyridine; trimethylsilyl bromide; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1021/jm0607294

upstream raw materials:

β-benzyl N-(diethoxyphosphinoyl)acetyl-L-isoasparaginate

β-benzyl N-chloroacetyl-L-isoasparaginate

(S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid

N-t-butyloxycarbonyl-L-aspartic acid β-benzyl ester α-amide