(4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline

Base Information

Chemical Name:(4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline
CAS No.:1367594-59-9
Molecular Formula:C₃₈H₅₁NO₇
Molecular Weight:633.825
Hs Code.:

(4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline

Synonyms:(4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline

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Chemical Property of (4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline

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Technology Process of (4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline

There total 8 articles about (4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1367595-39-8
(4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

: 74654-05-0
8-methoxy-1-(methylsulfonyl)oxy-3,6-dioxaoctane

: 1367594-59-9
(4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline

Guidance literature:: (4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol; With sodium hydride; In dimethyl sulfoxide; mineral oil; for 0.166667h;

8-methoxy-1-(methylsulfonyl)oxy-3,6-dioxaoctane; In dimethyl sulfoxide; mineral oil; at 20 ℃;

Reference yield:

: 2579-67-1
northebaine

: 1367594-59-9
(4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 90 °C

2.1: Reflux

3.1: boron tribromide / ethanol; chloroform / 20 °C / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

7.2: 20 °C

8.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.17 h

8.2: 20 °C

With lithium aluminium tetrahydride; hydrogen; boron tribromide; sodium hydride; sodium hydrogencarbonate; potassium carbonate; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 5083-80-7
N-(cyclopropylmethyl)northebaine

: 1367594-59-9
(4R,4aS,6R,7R,7aR,12bS)-6-((benzyloxy)methyl)-3-(cyclopropylmethyl)-9-methoxy-7-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: Reflux

2.1: boron tribromide / ethanol; chloroform / 20 °C / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

6.2: 20 °C

7.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.17 h

7.2: 20 °C

With lithium aluminium tetrahydride; hydrogen; boron tribromide; sodium hydride; potassium carbonate; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;