N-(5-chloro-2-methoxy-4-nitrophenyl)-1-<(4-methoxyphenyl)methyl>-4-piperidinecarboxamide

Base Information

Chemical Name:N-(5-chloro-2-methoxy-4-nitrophenyl)-1-<(4-methoxyphenyl)methyl>-4-piperidinecarboxamide
CAS No.:69082-63-9
Molecular Formula:C₂₁H₂₄ClN₃O₅
Molecular Weight:433.892
Hs Code.:

Synonyms:N-(5-chloro-2-methoxy-4-nitrophenyl)-1-<(4-methoxyphenyl)methyl>-4-piperidinecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-chloro-2-methoxy-4-nitrophenyl)-1-<(4-methoxyphenyl)methyl>-4-piperidinecarboxamide

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Technology Process of N-(5-chloro-2-methoxy-4-nitrophenyl)-1-<(4-methoxyphenyl)methyl>-4-piperidinecarboxamide

There total 5 articles about N-(5-chloro-2-methoxy-4-nitrophenyl)-1-<(4-methoxyphenyl)methyl>-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 69082-75-3
N-(5-chloro-2-methoxy-4-nitrophenyl)-4-piperidinecarboxamide

: 824-94-2
p-methoxybenzyl chloride

: 69082-63-9
N-(5-chloro-2-methoxy-4-nitrophenyl)-1-<(4-methoxyphenyl)methyl>-4-piperidinecarboxamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 16h;
DOI:10.1021/jm00366a017

Reference yield:

: ethyl acetate-petrol ether

: 69082-75-3
N-(5-chloro-2-methoxy-4-nitrophenyl)-4-piperidinecarboxamide

: 824-94-2
p-methoxybenzyl chloride

: 4-chloro-2-[1-(4-methylbenzyl)piperidine-4-carboxamido]anisole hydrochloride monohydrate

: 69082-63-9
N-(5-chloro-2-methoxy-4-nitrophenyl)-1-<(4-methoxyphenyl)methyl>-4-piperidinecarboxamide

Guidance literature:: With sodium hydroxide; potassium carbonate; In N-methyl-acetamide; ethyl acetate;

Reference yield:

: 69082-74-2
4-Chloro-2-(4-pyridinecarboxamido)anisole hydrochloride

: 69082-63-9
N-(5-chloro-2-methoxy-4-nitrophenyl)-1-<(4-methoxyphenyl)methyl>-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / H₂ / PtO₂ / ethanol / 6 h / 70 °C / 15514.4 Torr

2: 82 percent / fuming HNO₃, H₂SO₄ / acetic acid / 2 h

3: 68 percent / K₂CO₃ / dimethylformamide / 16 h

With sulfuric acid; hydrogen; nitric acid; potassium carbonate; platinum(IV) oxide; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00366a017