diethyl 2-(2-cyano-3-(4-methoxyphenylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)malonate

Base Information

Chemical Name:diethyl 2-(2-cyano-3-(4-methoxyphenylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)malonate
CAS No.:1248705-84-1
Molecular Formula:C₂₅H₂₅F₃N₂O₆
Molecular Weight:506.479
Hs Code.:

Synonyms:diethyl 2-(2-cyano-3-(4-methoxyphenylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2-(2-cyano-3-(4-methoxyphenylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)malonate

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Technology Process of diethyl 2-(2-cyano-3-(4-methoxyphenylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)malonate

There total 1 articles about diethyl 2-(2-cyano-3-(4-methoxyphenylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5382-38-7
2-cyano-N-(4-methoxyphenyl)acetamide

: 905451-26-5
diethyl 2-[4-(trifluoromethyl)benzylidene]malonate

: 1248705-84-1
diethyl 2-(2-cyano-3-(4-methoxyphenylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)malonate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 25 ℃; Inert atmosphere;
DOI:10.1021/jo1014245

Reference yield: 66.0%

: 1248705-84-1
diethyl 2-(2-cyano-3-(4-methoxyphenylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)malonate

: ethyl 2-cyano-2-((4-methoxyphenyl)carbamoyl)-3-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxylate

Guidance literature:: With iodosylbenzene; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 25 ℃; for 1h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo1014245