N₁-((1-methyl-1H-imidazol-2-yl)methyl)-N-((1-(pyridin-3-yl)cyclohexyl)methyl)-1H-indole-2-carboxamide

Base Information

• Chemical Name: N₁-((1-methyl-1H-imidazol-2-yl)methyl)-N-((1-(pyridin-3-yl)cyclohexyl)methyl)-1H-indole-2-carboxamide
• CAS No.: 1119281-74-1
• Molecular Formula: C₂₆H₂₉N₅O
• Molecular Weight: 427.549

Synonyms:N₁-((1-methyl-1H-imidazol-2-yl)methyl)-N-((1-(pyridin-3-yl)cyclohexyl)methyl)-1H-indole-2-carboxamide

Chemical Property of N₁-((1-methyl-1H-imidazol-2-yl)methyl)-N-((1-(pyridin-3-yl)cyclohexyl)methyl)-1H-indole-2-carboxamide

Chemical Property:

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Technology Process of N₁-((1-methyl-1H-imidazol-2-yl)methyl)-N-((1-(pyridin-3-yl)cyclohexyl)methyl)-1H-indole-2-carboxamide

There total 6 articles about N₁-((1-methyl-1H-imidazol-2-yl)methyl)-N-((1-(pyridin-3-yl)cyclohexyl)methyl)-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-(pyridin-3-yl)cyclohexyl)methanamine (1104276-48-3) + 1-((1-methyl-1H-imidazol-2-yl)methyl)-1H-indole-2-carboxylic acid (1097041-84-3) → N1-((1-methyl-1H-imidazol-2-yl)methyl)-N-((1-(pyridin-3-yl)cyclohexyl)methyl)-1H-indole-2-carboxamide (1119281-74-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

3-pyridinylacetonitrile (6443-85-2) → N1-((1-methyl-1H-imidazol-2-yl)methyl)-N-((1-(pyridin-3-yl)cyclohexyl)methyl)-1H-indole-2-carboxamide (1119281-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; dimethyl sulfoxide; mineral oil / 0 - 20 °C

2: ammonia; hydrogen / nickel / methanol / 2585.81 Torr

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With ammonia; hydrogen; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; nickel; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

1,5-dibromo-pentane (111-24-0) → N1-((1-methyl-1H-imidazol-2-yl)methyl)-N-((1-(pyridin-3-yl)cyclohexyl)methyl)-1H-indole-2-carboxamide (1119281-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; dimethyl sulfoxide; mineral oil / 0 - 20 °C

2: ammonia; hydrogen / nickel / methanol / 2585.81 Torr

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With ammonia; hydrogen; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; nickel; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

(1-(pyridin-3-yl)cyclohexyl)methanamine

1-((1-methyl-1H-imidazol-2-yl)methyl)-1H-indole-2-carboxylic acid

3-pyridinylacetonitrile

1,5-dibromo-pentane

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