2-tert-butoxycarbonylamino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

Base Information

Chemical Name:2-tert-butoxycarbonylamino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester
CAS No.:338735-86-7
Molecular Formula:C₂₂H₂₉F₃N₄O₆
Molecular Weight:502.491
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-5-[2-nitro-4-(3-trifluoromethyl-3<i>H</i>-diazirin-3-yl)-phenyl]-pentanoic acid <i>tert</i>-butyl ester

Synonyms:2-tert-butoxycarbonylamino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

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Chemical Property of 2-tert-butoxycarbonylamino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

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Technology Process of 2-tert-butoxycarbonylamino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

There total 7 articles about 2-tert-butoxycarbonylamino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 71432-55-8
2-tert-butyl-1,3-diisopropylisourea

: 338735-85-6
2-tert-butoxycarbonylamino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid

: 338735-86-7
2-tert-butoxycarbonylamino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

Guidance literature:: In dichloromethane; for 12h; Heating;
DOI:10.3987/com-00-s(i)90

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 338735-86-7
2-tert-butoxycarbonylamino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Et₃N / dioxane; H₂O / 12 h / 20 °C

2: 93 percent / CH₂Cl₂ / 12 h / Heating

With triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.3987/com-00-s(i)90

Reference yield:

: 271252-22-3
3-(azi-2,2,2-trifluoroethyl)-6-(3-bromopropyl)-1-nitrobenzene

: 338735-86-7
2-tert-butoxycarbonylamino-5-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 53 percent / NaH / dimethylformamide / 24 h / 20 °C

2: 100 percent / aq. NaOH / ethanol; H₂O / 20 °C

3: dioxane / 1 h / 80 °C

4: 29 percent / aq. NaOH; CoCl₂; Aspergillus genus enzyme / aq. phosphate buffer / 48 h / 35 - 38 °C / pH 6.7

5: 97 percent / Et₃N / dioxane; H₂O / 12 h / 20 °C

6: 93 percent / CH₂Cl₂ / 12 h / Heating

With sodium hydroxide; Aspergillus genus enzyme; sodium hydride; triethylamine; In 1,4-dioxane; phosphate buffer; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3987/com-00-s(i)90