ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate

Base Information

• Chemical Name: ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate
• CAS No.: 223127-85-3
• Molecular Formula: C₂₅H₂₆N₂O₅
• Molecular Weight: 434.492

Synonyms:ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate

Chemical Property of ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate

Chemical Property:

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Technology Process of ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate

There total 1 articles about ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-hydroxypropionate (223127-87-5) + 4-(pyridin-2-yl)benzoyl chloride hydrochloride (223128-24-3) → ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (223127-85-3)

Guidance literature:

With triethylamine;

Reference yield:

ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (223127-85-3) + Diethyl azocarboxylate + 2-Butyl-3-[4-[2-(3'-dimethylaminomethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionic acid (223122-00-7) + 4-hydroxybenzotrifluoride (402-45-9) + diethylazodicarboxylate (1972-28-7,218603-74-8) → ethyl 3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-(4-trifluoromethylphenoxy)propionate (223125-78-8)

Guidance literature:

With triphenylphosphine; In toluene;

Reference yield:

ethyl 2-hydroxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (223127-85-3) + 2,3,4,5,6-pentafluorophenol (771-61-9) + diethylazodicarboxylate (1972-28-7,218603-74-8) → ethyl 2-pentafluorophenoxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (223126-00-9)

Guidance literature:

With triphenylphosphine;

upstream raw materials:

ethyl 3-[4-(2-t-butoxycarbonylaminoethoxy)phenyl]-2-hydroxypropionate

4-(pyridin-2-yl)benzoyl chloride hydrochloride

Downstream raw materials:

ethyl 2-pentafluorophenoxy-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate

ethyl 2-(3-fluorophenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate

ethyl 2-(3,4-difluorophenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate

ethyl 3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]-2-(4-trifluoromethylphenoxy)propionate

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