apogossypol

Base Information

• Chemical Name: apogossypol
• CAS No.: 784206-41-3
• Molecular Formula: C₂₈H₃₀O₆
• Molecular Weight: 462.543
• Mol file: 784206-41-3.mol

Synonyms:apogossypol

Chemical Property of apogossypol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of apogossypol

There total 12 articles about apogossypol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(±)-gossypol acetic acid (5453-04-3,866541-93-7,1189561-66-7) → apogossypol (784206-41-3,475-56-9)

Guidance literature:

With sodium hydroxide; In water; at 95 ℃; for 0.5h;

DOI:10.1002/ardp.200800185

Reference yield: 95.0%

(rac)-gossypol (303-45-7) → apogossypol (784206-41-3,475-56-9)

Guidance literature:

(rac)-gossypol; With sodium hydroxide; acetic acid; In water; at 90 ℃; for 3.5h; darkness;

With sulfuric acid; In water; at 0 ℃;

Reference yield: 90.0%

5,5'-diisopropyl-1,1',6,6',7,7'-hexamethoxy-3,3'-dimethyl-2,2'-binaphthalene (7144-61-8,174693-02-8) → apogossypol (784206-41-3,475-56-9)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - -10 ℃; for 9h; Cooling with acetone-dry ice;

upstream raw materials:

(rac)-gossypol

4,4'-dihydroxy-5,5'-diisopropyl-7,7'-dimethyl-bis(3H-naphtho[1,8-bc]furan-3-one)

5,5'-diisopropyl-1,1',6,6',7,7'-hexamethoxy-3,3'-dimethyl-2,2'-binaphthalene

(±)-gossypol acetic acid

Downstream raw materials:

acetic acid 1,7,1',6',7'-pentaacetoxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2']binaphthalenyl-6-yl ester

(rac)-gossypol

apogossypolone

1,1',6,6',7,7'-hexamethoxy-3,3'-dimethyl-N₅,N₅'-bis(3-methylbenzyl)-2,2'-binaphthyl-5,5'-dicarboxamide