9-{(2R,5S,6R)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-1,9-dihydro-purin-6-one

Base Information

Chemical Name:9-{(2R,5S,6R)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-1,9-dihydro-purin-6-one
CAS No.:207674-28-0
Molecular Formula:C₃₂H₃₂N₄O₆
Molecular Weight:568.629
Hs Code.:

Synonyms:9-{(2R,5S,6R)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-1,9-dihydro-purin-6-one

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Chemical Property of 9-{(2R,5S,6R)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-1,9-dihydro-purin-6-one

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Technology Process of 9-{(2R,5S,6R)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-1,9-dihydro-purin-6-one

There total 5 articles about 9-{(2R,5S,6R)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-1,9-dihydro-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 207674-15-5
9-(2',3'-Dideoxy-β-D-glucopyranosyl)hypoxanthin

: 207674-28-0
9-{(2R,5S,6R)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-1,9-dihydro-purin-6-one

Guidance literature:: With tetrabutylammonium perchlorate; In pyridine; for 1h; Ambient temperature;
DOI:10.1002/hlca.19980810302

Reference yield:

: 35657-27-3
(2',3'-dideoxy-1-β-D-glucopyranosyl)adenine

: 207674-28-0
9-{(2R,5S,6R)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / NaNO₂, AcOH / acetone; H₂O / 28 h / Ambient temperature

2: 83 percent / (Bu₄N)ClO₄ / pyridine / 1 h / Ambient temperature

With tetrabutylammonium perchlorate; acetic acid; sodium nitrite; In pyridine; water; acetone;
DOI:10.1002/hlca.19980810302

Reference yield:

: 145593-73-3
(+)-[(2R,3S,6S)-2-(benzoyloxymethyl)-6-methoxyoxan-3-yl] benzoate

: 207674-28-0
9-{(2R,5S,6R)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 37 percent / N,O-bis(trimethylsilyl)acetamide, trimethylsilyl trifluoromethanesulfonate / acetonitrile / 22 h / 100 °C

2: 93 percent / NH₃ / methanol / 24 h / Ambient temperature

3: 83 percent / (Bu₄N)ClO₄ / pyridine / 1 h / Ambient temperature

With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; tetrabutylammonium perchlorate; ammonia; In pyridine; methanol; acetonitrile;
DOI:10.1002/hlca.19980810302