2,2-Dimethyl-N-{2-[(1S,3S,5R)-3-((E)-1-triisopropylsilanyloxymethyl-propenyl)-6-oxa-bicyclo[3.1.0]hexane-1-carbonyl]-phenyl}-propionamide

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Chemical Name:2,2-Dimethyl-N-{2-[(1S,3S,5R)-3-((E)-1-triisopropylsilanyloxymethyl-propenyl)-6-oxa-bicyclo[3.1.0]hexane-1-carbonyl]-phenyl}-propionamide
CAS No.:134031-38-2
Molecular Formula:C₃₀H₄₇NO₄Si
Molecular Weight:513.793
Hs Code.:

Synonyms:2,2-Dimethyl-N-{2-[(1S,3S,5R)-3-((E)-1-triisopropylsilanyloxymethyl-propenyl)-6-oxa-bicyclo[3.1.0]hexane-1-carbonyl]-phenyl}-propionamide

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Chemical Property of 2,2-Dimethyl-N-{2-[(1S,3S,5R)-3-((E)-1-triisopropylsilanyloxymethyl-propenyl)-6-oxa-bicyclo[3.1.0]hexane-1-carbonyl]-phenyl}-propionamide

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Technology Process of 2,2-Dimethyl-N-{2-[(1S,3S,5R)-3-((E)-1-triisopropylsilanyloxymethyl-propenyl)-6-oxa-bicyclo[3.1.0]hexane-1-carbonyl]-phenyl}-propionamide

There total 15 articles about 2,2-Dimethyl-N-{2-[(1S,3S,5R)-3-((E)-1-triisopropylsilanyloxymethyl-propenyl)-6-oxa-bicyclo[3.1.0]hexane-1-carbonyl]-phenyl}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134031-37-1
(E)-4-<1-(((triisopropylsilyl)oxy)methyl)-1-propenyl>-1-<1-(2-trimethylacetamido)benzoyl>cyclopentene

: 134031-38-2
(+/-)-(1R*,2S*,4S*)-4-<(1-((triisopropylsilyl)oxy)methyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)benzoyl)>-6-oxabicyclo<3.1.0>hexane

Guidance literature:: With tert.-butylhydroperoxide; N-benzyl-trimethylammonium hydroxide; In tetrahydrofuran; at -23 ℃; for 2h;

Reference yield:

: 930-30-3
cyclopent-2-enone

: 134031-38-2
(+/-)-(1R*,2S*,4S*)-4-<(1-((triisopropylsilyl)oxy)methyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)benzoyl)>-6-oxabicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) t-BuLi, 2.) 2-thienylCuCNLi, 3.) Me₃SiCl

2: 91 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

3: 1.) 1,1,3,3-tetramethyl-1,3-diphenyl-disilazane, n-BuLi, 3.) Pd(PPh₃)4

4: 1.) MeLi, 2.) t-BuLi

5: t-BuOOH, Triton B / tetrahydrofuran / 2 h / -23 °C

With tert.-butylhydroperoxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; chloro-trimethyl-silane; 1,1,3,3-tetramethyl-1,3-diphenyldisilazane; methyllithium; tert.-butyl lithium; N-benzyl-trimethylammonium hydroxide; thien-2-yl(cyano)copper lithium; In tetrahydrofuran; dichloromethane;

Reference yield:

: 134031-33-7
(E)-3-<1-(hydroxymethyl)-1-propenyl>cyclopentanone

: 134031-38-2
(+/-)-(1R*,2S*,4S*)-4-<(1-((triisopropylsilyl)oxy)methyl)-1-(E)-propenyl>-1-<1-(2-(trimethylacetamido)benzoyl)>-6-oxabicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

2: 1.) 1,1,3,3-tetramethyl-1,3-diphenyl-disilazane, n-BuLi, 3.) Pd(PPh₃)4

3: 1.) MeLi, 2.) t-BuLi

4: t-BuOOH, Triton B / tetrahydrofuran / 2 h / -23 °C

With tert.-butylhydroperoxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; 1,1,3,3-tetramethyl-1,3-diphenyldisilazane; methyllithium; tert.-butyl lithium; N-benzyl-trimethylammonium hydroxide; In tetrahydrofuran; dichloromethane;