4-(4-benzylpiperazin-1-yl)-5,6,7-triethoxyquinazoline

Base Information

Chemical Name:4-(4-benzylpiperazin-1-yl)-5,6,7-triethoxyquinazoline
CAS No.:1426170-13-9
Molecular Formula:C₂₅H₃₂N₄O₃
Molecular Weight:436.554
Hs Code.:

Synonyms:4-(4-benzylpiperazin-1-yl)-5,6,7-triethoxyquinazoline

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Chemical Property of 4-(4-benzylpiperazin-1-yl)-5,6,7-triethoxyquinazoline

Chemical Property:

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Technology Process of 4-(4-benzylpiperazin-1-yl)-5,6,7-triethoxyquinazoline

There total 7 articles about 4-(4-benzylpiperazin-1-yl)-5,6,7-triethoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.9%

: 2759-28-6
1-phenylmethylpiperazine

: 1419611-24-7
4-chloro-5,6,7-triethoxyquinazoline

: 1426170-13-9
4-(4-benzylpiperazin-1-yl)-5,6,7-triethoxyquinazoline

Guidance literature:: With triethylamine; In ethanol; Reflux;
DOI:10.1016/j.ejmech.2014.03.036

Reference yield:

: 610-02-6
2,3,4-trihydroxybenzoic acid

: 1426170-13-9
4-(4-benzylpiperazin-1-yl)-5,6,7-triethoxyquinazoline

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / water / 6 h / Reflux

2: sulfuric acid / 10 h / Reflux

3: nitric acid / 0.17 h / 0 °C

4: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C

5: trichlorophosphate / toluene / 5 h / 100 °C / Inert atmosphere

6: trichlorophosphate; triethylamine

7: triethylamine / ethanol / Reflux

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; triethylamine; sodium hydroxide; trichlorophosphate; In ethanol; water; toluene;
DOI:10.1016/j.ejmech.2014.03.036

Reference yield:

: 2,3,4-triethoxybenzoic acid

: 1426170-13-9
4-(4-benzylpiperazin-1-yl)-5,6,7-triethoxyquinazoline

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 10 h / Reflux

2: nitric acid / 0.17 h / 0 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C

4: trichlorophosphate / toluene / 5 h / 100 °C / Inert atmosphere

5: trichlorophosphate; triethylamine

6: triethylamine / ethanol / Reflux

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; triethylamine; trichlorophosphate; In ethanol; toluene;
DOI:10.1016/j.ejmech.2014.03.036