diethyl [(tert-butoxycarbonyl)amino](3-iodo-benzyl)malonate

Base Information

• Chemical Name: diethyl [(tert-butoxycarbonyl)amino](3-iodo-benzyl)malonate
• CAS No.: 856222-40-7
• Molecular Formula: C₁₉H₂₆INO₆
• Molecular Weight: 491.323
• Mol file: 856222-40-7.mol

Synonyms:diethyl [(tert-butoxycarbonyl)amino](3-iodo-benzyl)malonate

Chemical Property of diethyl [(tert-butoxycarbonyl)amino](3-iodo-benzyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl [(tert-butoxycarbonyl)amino](3-iodo-benzyl)malonate

There total 1 articles about diethyl [(tert-butoxycarbonyl)amino](3-iodo-benzyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethyl tert-butoxycarbonylaminomalonate (102831-44-7) + m-Iodobenzyl bromide (49617-83-6) → diethyl [(tert-butoxycarbonyl)amino](3-iodo-benzyl)malonate (856222-40-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;

Reference yield: 67.0%

diethyl [(tert-butoxycarbonyl)amino](3-iodo-benzyl)malonate (856222-40-7) → N-(tert-butoxycarbonyl)-3-iodo-phenylalanine (273221-73-1,273221-75-3)

Guidance literature:

diethyl [(tert-butoxycarbonyl)amino](3-iodo-benzyl)malonate; With sodium hydroxide; ethanol; water; for 3h; Heating / reflux;

With hydrogenchloride; water; In ethanol; at 20 ℃; pH=~ 2;

Reference yield:

diethyl [(tert-butoxycarbonyl)amino](3-iodo-benzyl)malonate (856222-40-7) → 2-amino-N-cyanomethyl-3-(3-iodo-phenyl)-propionamide

Guidance literature:

Multi-step reaction with 3 steps

1: aq. AcOH / 16 h / pH 5 / Heating

2: HOBT; EDCI; N-methylmorpholine / CH₂Cl₂ / 16 h / 20 °C

3: HCOOH / 6 h / 20 °C

With 4-methyl-morpholine; formic acid; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1021/jm010206q

upstream raw materials:

diethyl tert-butoxycarbonylaminomalonate

m-Iodobenzyl bromide

Downstream raw materials:

N-(tert-butoxycarbonyl)-3-iodo-phenylalanine