2-(3,5-Difluoro-4-methoxy-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol

Base Information

Chemical Name:2-(3,5-Difluoro-4-methoxy-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol
CAS No.:1027179-51-6
Molecular Formula:C₁₈H₁₅F₅N₂O₄S
Molecular Weight:450.386
Hs Code.:

Synonyms:2-(3,5-Difluoro-4-methoxy-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol

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Chemical Property of 2-(3,5-Difluoro-4-methoxy-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol

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Technology Process of 2-(3,5-Difluoro-4-methoxy-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol

There total 3 articles about 2-(3,5-Difluoro-4-methoxy-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 431-35-6
3-bromo-1,1,1-trifluoroacetone

: 3,5-Difluoro-N-(4-methanesulfonyl-phenyl)-4-methoxy-benzamidine

: 1027179-51-6
2-(3,5-Difluoro-4-methoxy-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol

Guidance literature:: With sodium hydrogencarbonate; In isopropyl alcohol; at 75 - 80 ℃; for 20h;
DOI:10.1021/jm9700225

Reference yield:

: 104197-15-1
3,5-difluoro-4-methoxybenzonitrile

: 1027179-51-6
2-(3,5-Difluoro-4-methoxy-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

2: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 75 - 80 °C

With trimethylaluminum; sodium hydrogencarbonate; In isopropyl alcohol;
DOI:10.1021/jm9700225

Reference yield:

: 134227-45-5
3,4,5-trifluorobenzonitrile

: 1027179-51-6
2-(3,5-Difluoro-4-methoxy-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / 20 h / Ambient temperature

2: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

3: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 75 - 80 °C

With trimethylaluminum; sodium methylate; sodium hydrogencarbonate; In isopropyl alcohol;
DOI:10.1021/jm9700225