6-(4-(2-((tert-butyldiphenylsilyl)oxy)ethoxy)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

Base Information

Chemical Name:6-(4-(2-((tert-butyldiphenylsilyl)oxy)ethoxy)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
CAS No.:1010801-13-4
Molecular Formula:C₂₉H₃₄N₂O₃Si
Molecular Weight:486.686
Hs Code.:

Synonyms:6-(4-(2-((tert-butyldiphenylsilyl)oxy)ethoxy)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

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Chemical Property of 6-(4-(2-((tert-butyldiphenylsilyl)oxy)ethoxy)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

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Technology Process of 6-(4-(2-((tert-butyldiphenylsilyl)oxy)ethoxy)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

There total 1 articles about 6-(4-(2-((tert-butyldiphenylsilyl)oxy)ethoxy)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 139897-19-1
(2-bromoethoxy)(tert-butyl)diphenylsilane

: 103416-88-2
6-(4-hydroxyphenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one

: 1010801-13-4
6-(4-(2-((tert-butyldiphenylsilyl)oxy)ethoxy)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

Guidance literature:: 6-(4-hydroxyphenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

(2-bromoethoxy)(tert-butyl)diphenylsilane; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.08.121

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1010801-13-4
6-(4-(2-((tert-butyldiphenylsilyl)oxy)ethoxy)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

: 1010801-14-5
2-t-Butoxycarbonyl-6-[4-[2-(t-butyldiphenylsilyloxy)ethoxy]phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2012.08.121

Reference yield:

: 1010801-13-4
6-(4-(2-((tert-butyldiphenylsilyl)oxy)ethoxy)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

: 1010801-64-5
C₂₇H₂₇F₃N₆O₄

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / acetonitrile / 2 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

3.1: 1H-imidazole; triphenylphosphine; iodine / tetrahydrofuran / 1 h / 20 °C

4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

4.2: 2 h / 0 - 80 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; iodine; sodium hydride; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.bmcl.2012.08.121