(R)-methyl 2-(4-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentyl)benzoate

Base Information

Chemical Name:(R)-methyl 2-(4-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentyl)benzoate
CAS No.:1587692-49-6
Molecular Formula:C₁₉H₂₇NO₆
Molecular Weight:365.426
Hs Code.:

Synonyms:(R)-methyl 2-(4-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentyl)benzoate

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Chemical Property of (R)-methyl 2-(4-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentyl)benzoate

Chemical Property:

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Technology Process of (R)-methyl 2-(4-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentyl)benzoate

There total 5 articles about (R)-methyl 2-(4-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1587692-47-4
(R)-methyl 2-(4-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopent-1-en-1-yl)benzoate

: 1587692-49-6
(R)-methyl 2-(4-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentyl)benzoate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; for 2h;
DOI:10.1016/j.bmcl.2014.02.058

Reference yield:

: 150652-96-3
(R)-2-(tert-butoxycarbonyl)amino-4-pentenoic acid methyl ester

: 1587692-49-6
(R)-methyl 2-(4-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; palladium diacetate / acetonitrile / 2 h / 130 °C / Microwave irradiation

2: 5%-palladium/activated carbon; hydrogen / methanol / 2 h

With 5%-palladium/activated carbon; hydrogen; palladium diacetate; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; 1: |Heck Reaction;
DOI:10.1016/j.bmcl.2014.02.058

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 1587692-49-6
(R)-methyl 2-(4-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 14.5 h / -10 - 20 °C

2: N-ethyl-N,N-diisopropylamine; palladium diacetate / acetonitrile / 2 h / 130 °C / Microwave irradiation

3: 5%-palladium/activated carbon; hydrogen / methanol / 2 h

With thionyl chloride; 5%-palladium/activated carbon; hydrogen; palladium diacetate; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; 2: |Heck Reaction;
DOI:10.1016/j.bmcl.2014.02.058