(R)-1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid

Base Information

Chemical Name:(R)-1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid
CAS No.:1310038-76-6
Molecular Formula:C₂₄H₂₀F₃NO₅S
Molecular Weight:491.488
Hs Code.:

Synonyms:(R)-1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid

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Chemical Property of (R)-1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid

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Technology Process of (R)-1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid

There total 4 articles about (R)-1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310038-53-9
1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid

: 1310038-72-2
(S)-1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid

: 1310038-76-6
(R)-1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid

Guidance literature:: With super critical fluid chromatography Diacel AD; In methanol; carbon dioxide; at 30 ℃; under 75007.5 Torr; Resolution of racemate;

Reference yield:

: C₂₈H₂₈F₃NO₅S

: 1310038-76-6
(R)-1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;
DOI:10.1039/c3md00053b

Reference yield:

: 1310036-90-8
4'-(3-bromomethyl-benzyloxy)-2,4,5-trifluoro-1,1'-biphenyl

: 1310038-72-2
(S)-1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid

: 1310038-76-6
(R)-1,1-dioxo-2-[3-(2',4',5'-trifluoro-biphenyl-4-yloxymethyl)-benzyl]-1λ6-isothiazolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

3: super critical fluid chromatography Diacel AD / methanol; carbon dioxide / 30 °C / 75007.5 Torr / Resolution of racemate

With potassium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; carbon dioxide; N,N-dimethyl-formamide;