4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl)-ester 5-benzyl ester

Base Information

Chemical Name:4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl)-ester 5-benzyl ester
CAS No.:228562-37-6
Molecular Formula:C₂₅H₂₃ClN₂O₄
Molecular Weight:450.922
Hs Code.:

Synonyms:4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl)-ester 5-benzyl ester

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Chemical Property of 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl)-ester 5-benzyl ester

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Technology Process of 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl)-ester 5-benzyl ester

There total 4 articles about 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl)-ester 5-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5396-89-4
benzyl acetoacetate

: 587-04-2
m-Chlorobenzaldehyde

: 193539-61-6
(Z)-3-Amino-but-2-enoic acid 2-cyano-ethyl ester

: 228562-37-6
4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl)-ester 5-benzyl ester

Guidance literature:: In isopropyl alcohol;
DOI:10.1016/j.bmcl.2005.11.021

Reference yield:

: 65193-87-5
2-cyanoethylacetoacetate

: 228562-37-6
4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl)-ester 5-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: AcONH₄ / propan-2-ol

2: propan-2-ol

With ammonium acetate; In isopropyl alcohol; 2: Hantzsch synthesis;
DOI:10.1016/j.bmcl.2005.11.021

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 228562-37-6
4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl)-ester 5-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / toluene

2: propan-2-ol

With triethylamine; In isopropyl alcohol; toluene; 2: Hantzsch synthesis;
DOI:10.1016/j.bmcl.2005.11.021