(5-methyl-6H-[1,3]dioxin-4-yl)-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester

Base Information

Chemical Name:(5-methyl-6H-[1,3]dioxin-4-yl)-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester
CAS No.:851592-87-5
Molecular Formula:C₂₉H₃₈O₅Si
Molecular Weight:494.703
Hs Code.:

(5-methyl-6<i>H</i>-[1,3]dioxin-4-yl)-acetic acid 1-[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester

Synonyms:(5-methyl-6H-[1,3]dioxin-4-yl)-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester

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Chemical Property of (5-methyl-6H-[1,3]dioxin-4-yl)-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester

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Technology Process of (5-methyl-6H-[1,3]dioxin-4-yl)-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester

There total 6 articles about (5-methyl-6H-[1,3]dioxin-4-yl)-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 851592-85-3
(5-methyl-[1,3]dioxan-4-ylidene)-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester

: 851592-87-5
(5-methyl-6H-[1,3]dioxin-4-yl)-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.0166667h;
DOI:10.1021/ol050270s

Reference yield:

: 851592-83-1
phenylsulfanyl-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester

: 851592-87-5
(5-methyl-6H-[1,3]dioxin-4-yl)-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran; hexane / -78 °C

1.2: 94 percent / tetrahydrofuran; hexane / -78 - -35 °C

2.1: BF₃*OEt₂ / CH₂Cl₂ / 0.25 h / 0 °C

3.1: 91 percent / m-CPBA / CH₂Cl₂ / 0.42 h / -78 °C

4.1: 22 percent / P(OEt)3 / m-xylene / 1 h / Heating

5.1: 76 percent / NaHMDS / tetrahydrofuran / 0.02 h / -78 °C

With boron trifluoride diethyl etherate; sodium hexamethyldisilazane; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; triethyl phosphite; In tetrahydrofuran; hexane; dichloromethane; m-xylene;
DOI:10.1021/ol050270s

Reference yield:

: 851770-87-1
(5-methyl-[1,3]dioxan-4-yl)-phenylsulfanyl-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester

: 851592-87-5
(5-methyl-6H-[1,3]dioxin-4-yl)-acetic acid 1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / m-CPBA / CH₂Cl₂ / 0.42 h / -78 °C

2: 22 percent / P(OEt)3 / m-xylene / 1 h / Heating

3: 76 percent / NaHMDS / tetrahydrofuran / 0.02 h / -78 °C

With sodium hexamethyldisilazane; 3-chloro-benzenecarboperoxoic acid; triethyl phosphite; In tetrahydrofuran; dichloromethane; m-xylene;
DOI:10.1021/ol050270s