(S)-4'-<<4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-yl>thio>acetophenone

Base Information

Chemical Name:(S)-4'-<<4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-yl>thio>acetophenone
CAS No.:161387-22-0
Molecular Formula:C₁₈H₂₀O₃S₂
Molecular Weight:348.487
Hs Code.:

Synonyms:(S)-4'-<<4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-yl>thio>acetophenone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4'-<<4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-yl>thio>acetophenone

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Technology Process of (S)-4'-<<4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-yl>thio>acetophenone

There total 7 articles about (S)-4'-<<4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-yl>thio>acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 161387-22-0
(S)-4'-<<4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-yl>thio>acetophenone

Guidance literature:

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 159615-89-1
2-mercapto-4-[(4S)-2,2,4-trimethyl-1,3-dioxolan-4-yl]thiophene

: 161387-22-0
(S)-4'-<<4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-yl>thio>acetophenone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 1.5h; Yield given;
DOI:10.1021/jm00020a008

Reference yield:

: 159615-81-3
2-bromo-4-isopropenylthiophen

: 161387-22-0
(S)-4'-<<4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-yl>thio>acetophenone

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) hexanes, ether, -70 deg C, 0.5 h, 2.) hexanes, ether, a) -70 deg C, 0.5 h, b) from -70 deg C to O deg C, 2 h

2: 92 percent / AD-mix-α, water / 2-methyl-propan-2-ol / 18 h / 0 °C

3: PTSA / acetone / 0.75 h / Heating

4: NaSMe / dimethylformamide / 0.5 h / 130 °C

5: K₂CO₃ / dimethylformamide / 1.5 h / 130 °C

With AD-mix-α; n-butyllithium; water; potassium carbonate; toluene-4-sulfonic acid; sodium thiomethoxide; In N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/jm00020a008