4-(3-cyclopropylmethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-2,5-difluorobenzonitrile

Base Information

Chemical Name:4-(3-cyclopropylmethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-2,5-difluorobenzonitrile
CAS No.:1073973-25-7
Molecular Formula:C₂₀H₁₉F₂N₃O
Molecular Weight:355.387
Hs Code.:

Synonyms:4-(3-cyclopropylmethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-2,5-difluorobenzonitrile

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Chemical Property of 4-(3-cyclopropylmethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-2,5-difluorobenzonitrile

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Technology Process of 4-(3-cyclopropylmethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-2,5-difluorobenzonitrile

There total 1 articles about 4-(3-cyclopropylmethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-2,5-difluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 129946-63-0
2,5-difluoro-4-cyano-phenylhydrazine

: 908117-02-2
2-(2-cyclopropylacetyl)-5,5-dimethylcyclohexane-1,3-dione

: 1073973-25-7
4-(3-cyclopropylmethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-2,5-difluorobenzonitrile

Guidance literature:: 2,5-difluoro-4-cyano-phenylhydrazine; 2-(2-cyclopropylacetyl)-5,5-dimethylcyclohexane-1,3-dione; With acetic acid; In ethanol; at 25 ℃; for 2h;

With sodium hydrogencarbonate; In ethanol; water; ethyl acetate;

Reference yield: 36.0%

: 1073973-25-7
4-(3-cyclopropylmethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-2,5-difluorobenzonitrile

: 111769-27-8,104530-80-5
(R)-3-aminotetrahydrofuranyl tosylate

: (R)-4-(3-(cyclopropylmethyl)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(tetrahydrofuran-3-ylamino)benzamide

Guidance literature:: 4-(3-cyclopropylmethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-2,5-difluorobenzonitrile; (R)-3-aminotetrahydrofuranyl tosylate; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃; for 48h;

With sodium hydroxide; water; dihydrogen peroxide; In ethanol; dimethyl sulfoxide; at 25 ℃; for 1h;