methyl 4-<<6-<(benzylsulfonyl)amino>indol-1-yl>methyl>-3-methoxybenzoate

Base Information

Chemical Name:methyl 4-<<6-<(benzylsulfonyl)amino>indol-1-yl>methyl>-3-methoxybenzoate
CAS No.:126848-52-0
Molecular Formula:C₂₅H₂₄N₂O₅S
Molecular Weight:464.542
Hs Code.:

Synonyms:methyl 4-<<6-<(benzylsulfonyl)amino>indol-1-yl>methyl>-3-methoxybenzoate

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Chemical Property of methyl 4-<<6-<(benzylsulfonyl)amino>indol-1-yl>methyl>-3-methoxybenzoate

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Technology Process of methyl 4-<<6-<(benzylsulfonyl)amino>indol-1-yl>methyl>-3-methoxybenzoate

There total 5 articles about methyl 4-<<6-<(benzylsulfonyl)amino>indol-1-yl>methyl>-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 104446-67-5
methyl 4-<(6-aminoindol-1-yl)methyl>-3-methoxybenzoate

: 1939-99-7
benzenesulfonyl chloride

: 126848-52-0
methyl 4-<<6-<(benzylsulfonyl)amino>indol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: With triethylamine; In dichloromethane; 1.) 0 deg C, 15 min, 2.) RT, 18 h;
DOI:10.1021/jm00168a036

Reference yield:

: 3556-83-0
methyl 4-methyl-3-methoxybenzoate

: 126848-52-0
methyl 4-<<6-<(benzylsulfonyl)amino>indol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / bromine / CCl₄ / 4 h / Irradiation

2: 95 percent / K₂CO₃ / acetone / 48 h / Heating

3: 95 percent / acetic acid-EtOAc, H₂ / 10percent Pd/C / 24 h / 2585.7 Torr

4: 55 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) RT, 18 h

With hydrogen; bromine; potassium carbonate; acetic acid; ethyl acetate; triethylamine; palladium on activated charcoal; In tetrachloromethane; dichloromethane; acetone;
DOI:10.1021/jm00168a036

Reference yield:

: 70264-94-7
methyl 4-(bromomethyl)-3-methoxybenzoate

: 126848-52-0
methyl 4-<<6-<(benzylsulfonyl)amino>indol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / K₂CO₃ / acetone / 48 h / Heating

2: 95 percent / acetic acid-EtOAc, H₂ / 10percent Pd/C / 24 h / 2585.7 Torr

3: 55 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) RT, 18 h

With hydrogen; potassium carbonate; acetic acid; ethyl acetate; triethylamine; palladium on activated charcoal; In dichloromethane; acetone;
DOI:10.1021/jm00168a036