(R)-(+)-4-(p-tolyl)-4-(trifluoromethyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide

Base Information

Chemical Name:(R)-(+)-4-(p-tolyl)-4-(trifluoromethyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide
CAS No.:1418635-43-4
Molecular Formula:C₁₅H₁₂F₃NO₃S
Molecular Weight:343.326
Hs Code.:

Synonyms:(R)-(+)-4-(p-tolyl)-4-(trifluoromethyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide

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Chemical Property of (R)-(+)-4-(p-tolyl)-4-(trifluoromethyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide

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Technology Process of (R)-(+)-4-(p-tolyl)-4-(trifluoromethyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide

There total 2 articles about (R)-(+)-4-(p-tolyl)-4-(trifluoromethyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 4-(trifluoromethyl)benzo[e][1,2,3]oxathiazine 2,2-dioxide

: 5720-05-8
4-methylphenylboronic acid

: 1418635-43-4
(R)-(+)-4-(p-tolyl)-4-(trifluoromethyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide

Guidance literature:: With palladium(II) trifluoroacetate; 2,2,2-trifluoroethanol; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol; at 40 ℃; for 72h; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.tetlet.2019.151280

Reference yield: 75.0%

: C₈H₆F₃NO₃S

: 5720-05-8
4-methylphenylboronic acid

: 1418635-43-4
(R)-(+)-4-(p-tolyl)-4-(trifluoromethyl)-3,4-dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide

Guidance literature:: C₈H₆F₃NO₃S; 4-methylphenylboronic acid; With chlorobis(cyclooctene)rhodium(I) dimer; C₁₈H₂₃NOS; In toluene; at 20 ℃; for 0.5h; Inert atmosphere;

With potassium fluoride; In water; toluene; at 20 ℃; for 3h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja3110818