triethylammonium S-phenyl 5'-O-(4,4'-dimethoxytrityl)-3-N-benzoylthymidine 3'-phosphorothioate

Base Information

• Chemical Name: triethylammonium S-phenyl 5'-O-(4,4'-dimethoxytrityl)-3-N-benzoylthymidine 3'-phosphorothioate
• CAS No.: 94189-77-2
• Molecular Formula: C₆H₁₅N*C₄₄H₄₁N₂O₁₀PS
• Molecular Weight: 922.048

Synonyms:triethylammonium S-phenyl 5'-O-(4,4'-dimethoxytrityl)-3-N-benzoylthymidine 3'-phosphorothioate

Chemical Property of triethylammonium S-phenyl 5'-O-(4,4'-dimethoxytrityl)-3-N-benzoylthymidine 3'-phosphorothioate

Chemical Property:

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Technology Process of triethylammonium S-phenyl 5'-O-(4,4'-dimethoxytrityl)-3-N-benzoylthymidine 3'-phosphorothioate

There total 8 articles about triethylammonium S-phenyl 5'-O-(4,4'-dimethoxytrityl)-3-N-benzoylthymidine 3'-phosphorothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Dithiophosphoric acid O-{(2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester (94219-34-8) + triethylamine (121-44-8) → triethylammonium S-phenyl 5'-O-(4,4'-dimethoxytrityl)-3-N-benzoylthymidine 3'-phosphorothioate (94189-77-2)

Guidance literature:

With hypophosphorous acid; In pyridine; at 40 ℃; for 0.25h;

DOI:10.1016/0040-4039(84)80055-6

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → triethylammonium S-phenyl 5'-O-(4,4'-dimethoxytrityl)-3-N-benzoylthymidine 3'-phosphorothioate (94189-77-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent

2: 91 percent

3: 88 percent / phosphinic acid / pyridine / 0.25 h / 40 °C

With hypophosphorous acid; In pyridine;

DOI:10.1016/0040-4039(84)80055-6

Reference yield:

N3-benzoyl thymidine (94189-75-0) → triethylammonium S-phenyl 5'-O-(4,4'-dimethoxytrityl)-3-N-benzoylthymidine 3'-phosphorothioate (94189-77-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent

2: 91 percent

3: 88 percent / phosphinic acid / pyridine / 0.25 h / 40 °C

With hypophosphorous acid; In pyridine;

DOI:10.1016/0040-4039(84)80055-6

upstream raw materials:

Dithiophosphoric acid O-{(2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester

triethylamine

4,4'-dimethoxytrityl chloride

N³-benzoyl thymidine

Downstream raw materials:

C₇₃H₆₆N₄O₁₆P₂S₃

Thiophosphorochloridic acid O-{(2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-phenyl ester

C₆₈H₆₁N₄O₁₆PS

(2,4,6-tribromophenyl)phosphate triester

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