2-BROMO-6-BENZOTHIAZOLECARBOXYLIC ACID

Base Information

• Chemical Name: 2-BROMO-6-BENZOTHIAZOLECARBOXYLIC ACID
• CAS No.: 22514-58-5
• Molecular Formula: C8H4 Br N O2 S
• Molecular Weight: 258.09186
• Hs Code.: 2934999090
• Mol file: 22514-58-5.mol

Synonyms:2-BROMO-6-BENZOTHIAZOLECARBOXYLIC ACID

Chemical Property of 2-BROMO-6-BENZOTHIAZOLECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.14E-08mmHg at 25°C
• Melting Point: 232-233℃ (dec.)
• Refractive Index: 1.753
• Boiling Point: 444.1°C at 760 mmHg
• PKA: 3.55±0.30(Predicted)
• Flash Point: 222.4°C
• PSA: 78.43000
• Density: 1.912
• LogP: 2.75700
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-6-benzothiazolecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-6-BENZOTHIAZOLECARBOXYLIC ACID

There total 3 articles about 2-BROMO-6-BENZOTHIAZOLECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-aminobenzo[d]thiazole-6-carboxylic acid methyl ester (66947-92-0) → 2-bromobenzo[d]thiazole-6-carboxylic acid (22514-58-5)

Guidance literature:

2-aminobenzo[d]thiazole-6-carboxylic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; at 0 - 20 ℃;

With hydrogenchloride; water; In tetrahydrofuran; pH=2;

Reference yield: 85.0%

2-bromobenzo[d]thiazole-6-carboxylic acid methyl ester (1024583-33-2) → 2-bromobenzo[d]thiazole-6-carboxylic acid (22514-58-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.bmcl.2008.02.079

Reference yield:

→ 2-bromobenzo[d]thiazole-6-carboxylic acid (22514-58-5)

Guidance literature:

2-Brom-6-methyl-benzothiazol, KMnO4;

upstream raw materials:

2-bromobenzo[d]thiazole-6-carboxylic acid methyl ester

2-aminobenzo[d]thiazole-6-carboxylic acid methyl ester

Downstream raw materials:

2-(4-aminophenyl)benzo[d]thiazole-6-carboxylic acid

(S)-tert-butyl 1-(4-(6-(3,4-dimethoxyphenylcarbamoyl)benzo[d]thiazol-2-yl)piperazin-1-yl)-1-oxo-3-(thiophen-2-yl)propan-2-ylcarbamate

(S)-tert-butyl 1-(4-(6-(3,4-dimethoxyphenylcarbamoyl)benzo[d]thiazol-2-yl)piperazin-1-yl)-1-oxobutan-2-ylcarbamate

2-bromo-N-(3,4-dimethoxyphenyl)benzo[d]thiazole-6-carboxamide

Refernces

• 1、 -. "BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS". Page/Page column 33-34. . Retrieved 2008/12/04.