2-chloro-6-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2 (1H)-yl)benzaldehyde

Base Information

Chemical Name:2-chloro-6-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2 (1H)-yl)benzaldehyde
CAS No.:1242156-54-2
Molecular Formula:C₁₉H₁₃ClFNO₂
Molecular Weight:341.769
Hs Code.:

Synonyms:2-chloro-6-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2 (1H)-yl)benzaldehyde

Suppliers and Price of 2-chloro-6-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2 (1H)-yl)benzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 2-chloro-6-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2 (1H)-yl)benzaldehyde

Chemical Property:

Purity/Quality:: 97% purity ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 2-chloro-6-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2 (1H)-yl)benzaldehyde

There total 8 articles about 2-chloro-6-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2 (1H)-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242157-23-8
4-bromo-2-fluoro-6-methylbenzoic acid

: 1242156-54-2
2-chloro-6-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2 (1H)-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole; ammonium hydroxide / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / Inert atmosphere; Resolution of racemate

3.1: 2-methyltetrahydrofuran / 60 °C / Inert atmosphere

3.2: 60 °C / Inert atmosphere

4.1: caesium carbonate; copper(l) iodide / 1,4-dioxane / 18 h / Inert atmosphere; Sealed tube; Heating

With ammonium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; potassium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; water; toluene;
DOI:10.1021/jm500305p

Reference yield:

: 1242156-51-9
4-bromo-2-fluoro-6-methylbenzamide

: 1242156-54-2
2-chloro-6-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2 (1H)-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / Inert atmosphere; Resolution of racemate

2.1: 2-methyltetrahydrofuran / 60 °C / Inert atmosphere

2.2: 60 °C / Inert atmosphere

3.1: caesium carbonate; copper(l) iodide / 1,4-dioxane / 18 h / Inert atmosphere; Sealed tube; Heating

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; potassium carbonate; caesium carbonate; In 2-methyltetrahydrofuran; 1,4-dioxane; water; toluene;
DOI:10.1021/jm500305p

Reference yield:

: 1242156-52-0
4-cyclopropyl-2-fluoro-6-methylbenzamide

: 1242156-54-2
2-chloro-6-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2 (1H)-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2-methyltetrahydrofuran / 60 °C / Inert atmosphere

1.2: 60 °C / Inert atmosphere

2.1: caesium carbonate; copper(l) iodide / 1,4-dioxane / 18 h / Inert atmosphere; Sealed tube; Heating

With copper(l) iodide; caesium carbonate; In 2-methyltetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm500305p