(R)-N-{(S)-1-[(S)-1-((S)-2-Ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-3-((S)-3-(4-hydroxy-phenyl)-2-{(S)-3-hydroxy-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionylamino)-succinamic acid

Base Information

Chemical Name:(R)-N-{(S)-1-[(S)-1-((S)-2-Ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-3-((S)-3-(4-hydroxy-phenyl)-2-{(S)-3-hydroxy-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionylamino)-succinamic acid
CAS No.:171976-95-7
Molecular Formula:C₄₀H₆₃N₁₁O₁₁
Molecular Weight:874.007
Hs Code.:

(R)-N-{(S)-1-[(S)-1-((S)-2-Ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-3-((S)-3-(4-hydroxy-phenyl)-2-{(S)-3-hydroxy-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionylamino)-succinamic acid

Synonyms:(R)-N-{(S)-1-[(S)-1-((S)-2-Ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-3-((S)-3-(4-hydroxy-phenyl)-2-{(S)-3-hydroxy-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionylamino)-succinamic acid

Suppliers and Price of (R)-N-{(S)-1-[(S)-1-((S)-2-Ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-3-((S)-3-(4-hydroxy-phenyl)-2-{(S)-3-hydroxy-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionylamino)-succinamic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-N-{(S)-1-[(S)-1-((S)-2-Ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-3-((S)-3-(4-hydroxy-phenyl)-2-{(S)-3-hydroxy-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionylamino)-succinamic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-N-{(S)-1-[(S)-1-((S)-2-Ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-3-((S)-3-(4-hydroxy-phenyl)-2-{(S)-3-hydroxy-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionylamino)-succinamic acid

There total 6 articles about (R)-N-{(S)-1-[(S)-1-((S)-2-Ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-3-((S)-3-(4-hydroxy-phenyl)-2-{(S)-3-hydroxy-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionylamino)-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58111-84-5
Z-L-Ser-L-Tyr-N₃

: 171976-95-7
(R)-N-{(S)-1-[(S)-1-((S)-2-Ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-3-((S)-3-(4-hydroxy-phenyl)-2-{(S)-3-hydroxy-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionylamino)-succinamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / dioxane / 1.) -30 deg C, 1 h, 2.) -15 deg C, 1 h, 3.) 0 deg C, 1 day, 4.) RT, 1 day

2: 73 percent / Et₃N, diphenylphosphorazidate / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 2 days

3: 94 percent / H₂, aq. AcOH / Pd/C / methanol

4: 73 percent / Et₃N / dimethylformamide / 48 h / pH 8

5: TFA / 0.5 h

With diphenyl phosphoryl azide; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1007/BF00629874

Reference yield:

: 55610-27-0
Z-L-Ser-L-Tyr-N₂H₃

: 171976-95-7
(R)-N-{(S)-1-[(S)-1-((S)-2-Ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-3-((S)-3-(4-hydroxy-phenyl)-2-{(S)-3-hydroxy-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionylamino)-succinamic acid

Guidance literature:: Multi-step reaction with 6 steps

1: tert-butyl nitrite, HCl / dioxane / 0.75 h / 0 °C

2: Et₃N / dioxane / 1.) -30 deg C, 1 h, 2.) -15 deg C, 1 h, 3.) 0 deg C, 1 day, 4.) RT, 1 day

3: 73 percent / Et₃N, diphenylphosphorazidate / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 2 days

4: 94 percent / H₂, aq. AcOH / Pd/C / methanol

5: 73 percent / Et₃N / dimethylformamide / 48 h / pH 8

6: TFA / 0.5 h

With hydrogenchloride; tert.-butylnitrite; diphenyl phosphoryl azide; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1007/BF00629874

Reference yield:

: 171976-97-9
Z-Ser-Tyr-D-Asp(OBzl)-Leu-Arg(NO₂)-Pro-NHEt

: 171976-95-7
(R)-N-{(S)-1-[(S)-1-((S)-2-Ethylcarbamoyl-pyrrolidine-1-carbonyl)-4-guanidino-butylcarbamoyl]-3-methyl-butyl}-3-((S)-3-(4-hydroxy-phenyl)-2-{(S)-3-hydroxy-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionylamino)-succinamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / H₂, aq. AcOH / Pd/C / methanol

2: 73 percent / Et₃N / dimethylformamide / 48 h / pH 8

3: TFA / 0.5 h

With hydrogen; acetic acid; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1007/BF00629874