tert-butyl 1-(2-pyridinyl)-3-(4-biphenyl)-4-benzyl-5-pyrazolyl carbonate

Base Information

• Chemical Name: tert-butyl 1-(2-pyridinyl)-3-(4-biphenyl)-4-benzyl-5-pyrazolyl carbonate
• CAS No.: 1323987-81-0
• Molecular Formula: C₃₂H₂₉N₃O₃
• Molecular Weight: 503.601
• Mol file: 1323987-81-0.mol

Synonyms:tert-butyl 1-(2-pyridinyl)-3-(4-biphenyl)-4-benzyl-5-pyrazolyl carbonate

Chemical Property of tert-butyl 1-(2-pyridinyl)-3-(4-biphenyl)-4-benzyl-5-pyrazolyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-(2-pyridinyl)-3-(4-biphenyl)-4-benzyl-5-pyrazolyl carbonate

There total 2 articles about tert-butyl 1-(2-pyridinyl)-3-(4-biphenyl)-4-benzyl-5-pyrazolyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tert-butyl 1-(2-pyridinyl)-3-(4-bromophenyl)-4-benzyl-5-pyrazolyl carbonate (1323987-78-5) + phenylboronic acid (98-80-6) → tert-butyl 1-(2-pyridinyl)-3-(4-biphenyl)-4-benzyl-5-pyrazolyl carbonate (1323987-81-0)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; at 100 ℃; for 1h;

DOI:10.1055/s-0030-1260018

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + C21H16BrN3O → tert-butyl 1-(2-pyridinyl)-3-(4-biphenyl)-4-benzyl-5-pyrazolyl carbonate (1323987-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / dichloromethane

2: potassium phosphate; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1 h / 100 °C

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; dichloromethane; 2: Suzuki-Miyaura cross-coupling;

DOI:10.1055/s-0030-1260018

Reference yield: 96.0%

tert-butyl 1-(2-pyridinyl)-3-(4-biphenyl)-4-benzyl-5-pyrazolyl carbonate (1323987-81-0) → 1-(2-pyridinyl)-3-(4-biphenyl)-4-benzyl-5-hydroxypyrazole (1323987-84-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1055/s-0030-1260018

upstream raw materials:

di-tert-butyl dicarbonate

tert-butyl 1-(2-pyridinyl)-3-(4-bromophenyl)-4-benzyl-5-pyrazolyl carbonate

phenylboronic acid

Downstream raw materials:

1-(2-pyridinyl)-3-(4-biphenyl)-4-benzyl-5-hydroxypyrazole