4-Pyrimidinemethanamine, 2-methyl- (9CI)

Base Information

• Chemical Name: 4-Pyrimidinemethanamine, 2-methyl- (9CI)
• CAS No.: 22454-79-1
• Molecular Formula: C6H9 N3
• Molecular Weight: 123.158
• Hs Code.: 2933599090
• Mol file: 22454-79-1.mol

Synonyms:Pyrimidine,4-(aminomethyl)-2-methyl- (8CI)

Chemical Property of 4-Pyrimidinemethanamine, 2-methyl- (9CI)

Chemical Property:

• Boiling Point: 217.3±15.0 °C(Predicted)
• PKA: 8.13±0.40(Predicted)
• PSA: 51.80000
• Density: 1.098±0.06 g/cm3(Predicted)
• LogP: 0.94400

Purity/Quality:

98%min ^*data from raw suppliers

2-Methyl-4-pyrimidinemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methyl-4-pyrimidinemethanamine is a useful compound in medicinal chemistry in the study of potent and selective GSK-3 inhibitors.

Technology Process of 4-Pyrimidinemethanamine, 2-methyl- (9CI)

There total 1 articles about 4-Pyrimidinemethanamine, 2-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-methyl-pyrimidine-4-carbaldehyde oxime (28840-37-1) → (2-methylpyrimidin-4-yl)methanamine (22454-79-1)

Guidance literature:

With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; at 40 ℃; for 2h;

Reference yield: 75.0%

(2-methylpyrimidin-4-yl)methanamine (22454-79-1) + 5-hydroxy-3-oxo-N-phenyl-3,6-dihydro-2H-pyran-4-carbothioamide → 5-{[(2-methylpyrimidin-4-yl)methyl]amino}-3-oxo-N-phenyl-3,6-dihydro-2H-pyran-4-carbothioamide

Guidance literature:

In N,N-dimethyl acetamide; at 80 ℃; for 1h; Microwave irradiation;

Reference yield: 49.0%

(2-methylpyrimidin-4-yl)methanamine (22454-79-1) + tert-butyl 5-hydroxy-3-oxo-4-(phenylcarbamothioyl)-3,6-dihydropyridine-1(2H)-carboxylate → tert-butyl 5-{[(2-methylpyrimidin-4-yl)methyl]amino}-3-oxo-4-(phenylcarbamothioyl)-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:

In N,N-dimethyl acetamide; at 120 ℃; for 1.5h; Microwave irradiation;

upstream raw materials:

2-methyl-pyrimidine-4-carbaldehyde oxime

Refernces