AC-PHE-TYR-OH

Base Information

• Chemical Name: AC-PHE-TYR-OH
• CAS No.: 2365-53-9
• Molecular Formula: C20H22 N2 O5
• Molecular Weight: 370.405
• Mol file: 2365-53-9.mol

Synonyms:L-Tyrosine,N-(N-acetyl-L-phenylalanyl)-; Tyrosine, N-(N-acetyl-3-phenyl-L-alanyl)- (7CI);Tyrosine, N-(N-acetyl-3-phenyl-L-alanyl)-, L- (8CI);N-Acetyl-L-phenylalanyl-L-tyrosine

Chemical Property of AC-PHE-TYR-OH

Chemical Property:

• Boiling Point: 751.4±60.0 °C(Predicted)
• PKA: 3.08±0.10(Predicted)
• PSA: 115.73000
• Density: 1.287±0.06 g/cm3(Predicted)
• LogP: 2.03330
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

Ac-Phe-Tyr-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AC-PHE-TYR-OH

There total 3 articles about AC-PHE-TYR-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

phenylmagnesium bromide + 2,3,4,5-tetraphenylcyclopenta-2,4-dienone (479-33-4) → Ac-Phe-Tyr (2365-53-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Product distribution; multistep reaction; other solvents; reaction of cyclones with PhM and subsequent reduction of reaction mixture, effect of arylating and reducing agents on the yield of product;

DOI:10.1007/BF00698457

Reference yield:

→ Ac-Phe-Tyr (2365-53-9) + Ac-D-Phe-L-Tyr (73942-36-6)

Guidance literature:

With methanol; palladium; Hydrogenation;

Reference yield:

N-Ac-Δ-Phe-Tyr (68762-65-2) → Ac-Phe-Tyr (2365-53-9) + Ac-D-Phe-L-Tyr (73942-36-6)

Guidance literature:

With hydrogen; magnesium sulfate; palladium on activated charcoal; Product distribution; asymmetric hydrogenation of N-acetyldehydrodepeptide complexes with Mg(II) and Ca(II) ions, effect of Mg and Ca ions on the diastereomeric excess of dipeptide formed;

DOI:10.1007/BF00698456

upstream raw materials:

N-Ac-Δ-Phe-Tyr

2,3,4,5-tetraphenylcyclopenta-2,4-dienone

Downstream raw materials:

Ac-Phe-3,5-di-iodo-Tyr

Refernces

• 1、 Lisichkina, I. N.,Vinogradova, A. I.,Sukhorukova, N. B.,Tselyapina, E. V.,Saporovskaya, M. B.,Belikov, V. M.. "Asymmetric hydrogenation of N-acetylhydrodipeptide complexes with Mg(II) and C(II) ions". . p. 569 - 571. Retrieved 2007/10/02.