(1R,2R)-1'-methyl-2-phenylspiro[cyclopropane-1,3'-indolin]-2'-one

Base Information

Chemical Name:(1R,2R)-1'-methyl-2-phenylspiro[cyclopropane-1,3'-indolin]-2'-one
CAS No.:1426228-31-0
Molecular Formula:C₁₇H₁₅NO
Molecular Weight:249.312
Hs Code.:

Synonyms:(1R,2R)-1'-methyl-2-phenylspiro[cyclopropane-1,3'-indolin]-2'-one

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Chemical Property of (1R,2R)-1'-methyl-2-phenylspiro[cyclopropane-1,3'-indolin]-2'-one

Chemical Property:

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Technology Process of (1R,2R)-1'-methyl-2-phenylspiro[cyclopropane-1,3'-indolin]-2'-one

There total 5 articles about (1R,2R)-1'-methyl-2-phenylspiro[cyclopropane-1,3'-indolin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426228-50-3
cis-N-(2-bromophenyl)-N-methyl-2-phenylcyclopropanecarboxamide

: 1426228-31-0
(1R,2R)-1'-methyl-2-phenylspiro[cyclopropane-1,3'-indolin]-2'-one

Guidance literature:: With silver orthophosphate; palladium diacetate; potassium carbonate; tricyclohexylphosphine; In toluene; at 130 ℃; for 3h; Inert atmosphere; Glovebox;
DOI:10.1021/ol4003338

Reference yield:

: 139492-31-2
(1R,2S)-cis-1-(Hydroxymethyl)-2-phenylcyclopropane

: 1426228-31-0
(1R,2R)-1'-methyl-2-phenylspiro[cyclopropane-1,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 4 steps

1: ruthenium(III) trichloride hydrate; sodium periodate / acetonitrile; tetrachloromethane; water / Inert atmosphere

2: N,N-dimethyl-formamide; oxalyl dichloride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: triethylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4: palladium diacetate; tricyclohexylphosphine; potassium carbonate; silver orthophosphate / toluene / 3 h / 130 °C / Inert atmosphere; Glovebox

With sodium periodate; silver orthophosphate; oxalyl dichloride; ruthenium(III) trichloride hydrate; palladium diacetate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; tricyclohexylphosphine; In tetrahydrofuran; tetrachloromethane; water; toluene; acetonitrile;
DOI:10.1021/ol4003338

Reference yield:

: C₁₀H₉ClO

: 1426228-31-0
(1R,2R)-1'-methyl-2-phenylspiro[cyclopropane-1,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2: palladium diacetate; tricyclohexylphosphine; potassium carbonate; silver orthophosphate / toluene / 3 h / 130 °C / Inert atmosphere; Glovebox

With silver orthophosphate; palladium diacetate; potassium carbonate; triethylamine; tricyclohexylphosphine; In tetrahydrofuran; toluene;
DOI:10.1021/ol4003338