2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1R-(α)-oxide

Base Information

• Chemical Name: 2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1R-(α)-oxide
• CAS No.: 24689-53-0
• Molecular Formula: C₁₈H₁₇Cl₃N₂O₆S
• Molecular Weight: 495.768

Synonyms:2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1R-(α)-oxide

Chemical Property of 2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1R-(α)-oxide

Chemical Property:

Purity/Quality:

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Technology Process of 2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1R-(α)-oxide

There total 2 articles about 2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1R-(α)-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

2,2,2-Trichloroethyl (6R,7R)-3-methyl-<(phenoxyacetyl)amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate (24647-47-0) → 2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide (24689-52-9) + 2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1R-(α)-oxide (24689-53-0)

Guidance literature:

With peracetic acid; In dichloromethane; at 20 - 30 ℃; for 0.05h;

DOI:10.1016/S0040-4020(01)91829-0

Reference yield:

2,2,2-Trichloroethyl (6R,7R)-3-methyl-<(phenoxyacetyl)amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate (24647-47-0) → 2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1R-(α)-oxide (24689-53-0)

Guidance literature:

With ethyl N,N-dichlorocarbamate; In dichloromethane; Ambient temperature;

Reference yield:

2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1R-(α)-oxide (24689-53-0) + acrylonitrile (107-13-1,25014-41-9) → (6R)-2-(2-cyano-ethyl)-3-methyl-5c,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid 2,2,2-trichloro-ethyl ester (61033-64-5)

Guidance literature:

With triethylamine;

DOI:10.1039/c39760000538

upstream raw materials:

2,2,2-Trichloroethyl (6R,7R)-3-methyl-<(phenoxyacetyl)amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

Downstream raw materials:

(6R)-2-(2-cyano-ethyl)-3-methyl-5c,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid 2,2,2-trichloro-ethyl ester

(6R)-2-(2-cyano-ethyl)-3-methyl-5c,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2c-carboxylic acid 2,2,2-trichloro-ethyl ester

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