1-(3-iodo-2-propynyl)-2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-3,3-dimethyl-1-butynyl>-2-cyclopenten-1-ol acetate

Base Information

Chemical Name:1-(3-iodo-2-propynyl)-2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-3,3-dimethyl-1-butynyl>-2-cyclopenten-1-ol acetate
CAS No.:158834-57-2
Molecular Formula:C₃₂H₃₇IO₃Si
Molecular Weight:624.634
Hs Code.:

Synonyms:1-(3-iodo-2-propynyl)-2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-3,3-dimethyl-1-butynyl>-2-cyclopenten-1-ol acetate

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Chemical Property of 1-(3-iodo-2-propynyl)-2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-3,3-dimethyl-1-butynyl>-2-cyclopenten-1-ol acetate

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Technology Process of 1-(3-iodo-2-propynyl)-2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-3,3-dimethyl-1-butynyl>-2-cyclopenten-1-ol acetate

There total 5 articles about 1-(3-iodo-2-propynyl)-2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-3,3-dimethyl-1-butynyl>-2-cyclopenten-1-ol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 158834-56-1
2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-3,3-dimethyl-1-butynyl>-1-(2-propynyl)-2-cyclopenten-1-ol acetate

: 158834-57-2
1-(3-iodo-2-propynyl)-2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-3,3-dimethyl-1-butynyl>-2-cyclopenten-1-ol acetate

Guidance literature:: With morpholine; iodine; In benzene; at 40 - 50 ℃;
DOI:10.1080/00397919408010554

Reference yield:

: 10481-34-2
2-bromo-2-cyclopenten-1-one

: 158834-57-2
1-(3-iodo-2-propynyl)-2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-3,3-dimethyl-1-butynyl>-2-cyclopenten-1-ol acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / (PPh₃)2PdCl₂, CuI, N,N-diisopropylamine / tetrahydrofuran / Heating

2: 89 percent / HgCl₂ / diethyl ether / 0.5 h / Ambient temperature

3: 84 percent / pyridine, 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

4: 89 percent / I₂, morpholine / benzene / 40 - 50 °C

With morpholine; pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; diisopropylamine; mercury dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1080/00397919408010554

Reference yield:

: tert-butyl[(2,2-dimethylbut-3-yn-1-yl)oxy]diphenylsilane

: 158834-57-2
1-(3-iodo-2-propynyl)-2-<4-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-3,3-dimethyl-1-butynyl>-2-cyclopenten-1-ol acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / (PPh₃)2PdCl₂, CuI, N,N-diisopropylamine / tetrahydrofuran / Heating

2: 89 percent / HgCl₂ / diethyl ether / 0.5 h / Ambient temperature

3: 84 percent / pyridine, 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

4: 89 percent / I₂, morpholine / benzene / 40 - 50 °C

With morpholine; pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; diisopropylamine; mercury dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1080/00397919408010554