dl-Biotin

Base Information

• Chemical Name: dl-Biotin
• CAS No.: 22377-59-9
• Molecular Formula: C₁₀H₁₆N₂O₃S
• Molecular Weight: 244.315
• Mol file: 22377-59-9.mol

Synonyms:1H-Thieno[3,4-d]imidazole-4-pentanoicacid, hexahydro-2-oxo-, (3aa,4b,6aa)-(?à)-; Biotin, (?à)- (8CI); (?à)-Biotin;1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aa,4b,6aa)-; DL-Biotin; dl-Biotin

Chemical Property of dl-Biotin

Chemical Property:

• PSA: 103.73000
• LogP: 1.45440

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dl-Biotin

There total 54 articles about dl-Biotin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C26H32N2O3S → (+/-)-biotin (58-85-5,4375-00-2,4443-68-9,5652-41-5,15720-24-8,21788-37-4,22377-59-9,57378-70-8,58073-87-3,68225-55-8,22879-79-4)

Guidance literature:

With bis(trichloromethyl) carbonate; water; hydrogen bromide; In 5,5-dimethyl-1,3-cyclohexadiene; Reflux;

DOI:10.1016/j.tetlet.2010.05.035

Reference yield: 50.0%

(+/-)-biotin methyl ester (608-16-2,60562-11-0) → (+/-)-biotin (58-85-5,4375-00-2,4443-68-9,5652-41-5,15720-24-8,21788-37-4,22377-59-9,57378-70-8,58073-87-3,68225-55-8,22879-79-4)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 12h;

DOI:10.1007/BF00953125

Reference yield:

(+/-)-biotin (58-85-5,4375-00-2,4443-68-9,5652-41-5,15720-24-8,21788-37-4,22377-59-9,57378-70-8,58073-87-3,68225-55-8,22879-79-4) → vitamin H (58-85-5,4375-00-2,4443-68-9,5652-41-5,15720-24-8,21788-37-4,22377-59-9,57378-70-8,58073-87-3,68225-55-8,22879-79-4)

Guidance literature:

With MANDELIC ACID;

DOI:10.1021/ja01228a013

upstream raw materials:

(+/-)-biotin

5-[(3aR)-1( oder !3)-benzyl-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl]-valeric acid

5-(2-oxo-2,3-dihydro-1H-thieno[3,4-d]imidazol-4-yl)-pentanoic acid

phosgene

Downstream raw materials:

5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid (3-phenyl-propyl)-amide

2,10-dimethoxy-9-(phenylsulfonyloxy)-5,6,7,8,13,13a-hexahydroisoquinolino[3,2-a]isoquinolin-3-yl 5-((5S,1R,2R)-7-oxo-3-thia-6,8-diazabicyclo[3.3.0]oct-2-yl)pentanoate

2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl 5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate

biotin