O-3-(2-triisopropylsilylethynyl)-2-(methylthio)phenyl N,N-diethylcarbamate

Base Information

• Chemical Name: O-3-(2-triisopropylsilylethynyl)-2-(methylthio)phenyl N,N-diethylcarbamate
• CAS No.: 1254063-75-6
• Molecular Formula: C₂₃H₃₇NO₂SSi
• Molecular Weight: 419.704
• Mol file: 1254063-75-6.mol

Synonyms:O-3-(2-triisopropylsilylethynyl)-2-(methylthio)phenyl N,N-diethylcarbamate

Chemical Property of O-3-(2-triisopropylsilylethynyl)-2-(methylthio)phenyl N,N-diethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of O-3-(2-triisopropylsilylethynyl)-2-(methylthio)phenyl N,N-diethylcarbamate

There total 1 articles about O-3-(2-triisopropylsilylethynyl)-2-(methylthio)phenyl N,N-diethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

O-3-bromo-2-(methylthio)phenyl N,N-diethylcarbamate (1254063-64-3) + tris-iso-propylsilyl acetylene (89343-06-6) → O-3-(2-triisopropylsilylethynyl)-2-(methylthio)phenyl N,N-diethylcarbamate (1254063-75-6)

Guidance literature:

O-3-bromo-2-(methylthio)phenyl N,N-diethylcarbamate; With dichloro bis(acetonitrile) palladium(II); caesium carbonate; XPhos; In acetonitrile; at 20 ℃; for 0.416667h; Inert atmosphere;

tris-iso-propylsilyl acetylene; In acetonitrile; at 45 ℃; for 45h; Inert atmosphere;

DOI:10.1021/jo101436f

Reference yield: 92.0%

O-3-(2-triisopropylsilylethynyl)-2-(methylthio)phenyl N,N-diethylcarbamate (1254063-75-6) → O-3-ethynyl-2-(methylthio)phenyl N,N-diethylcarbamate (1254063-88-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/jo101436f

upstream raw materials:

O-3-bromo-2-(methylthio)phenyl N,N-diethylcarbamate

tris-iso-propylsilyl acetylene

Downstream raw materials:

O-3-ethynyl-2-(methylthio)phenyl N,N-diethylcarbamate