ethyl-2,2-(3,3-diethoxypropyl)-6-methoxy-7-benzyloxyquinoline-3-carboxylate

Base Information

Chemical Name:ethyl-2,2-(3,3-diethoxypropyl)-6-methoxy-7-benzyloxyquinoline-3-carboxylate
CAS No.:350249-72-8
Molecular Formula:C₂₇H₃₃NO₆
Molecular Weight:467.562
Hs Code.:

Synonyms:ethyl-2,2-(3,3-diethoxypropyl)-6-methoxy-7-benzyloxyquinoline-3-carboxylate

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Chemical Property of ethyl-2,2-(3,3-diethoxypropyl)-6-methoxy-7-benzyloxyquinoline-3-carboxylate

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Technology Process of ethyl-2,2-(3,3-diethoxypropyl)-6-methoxy-7-benzyloxyquinoline-3-carboxylate

There total 5 articles about ethyl-2,2-(3,3-diethoxypropyl)-6-methoxy-7-benzyloxyquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 350249-67-1
ethyl-6,6-diethoxy-3-oxohexanoic acid

: 6-(p-tolylaminomethylidene)-3-benzyloxy-4-methoxyaniline

: 350249-72-8
ethyl-2,2-(3,3-diethoxypropyl)-6-methoxy-7-benzyloxyquinoline-3-carboxylate

Guidance literature:: With piperidine; In ethanol; for 24h; Heating;
DOI:10.1016/S0040-4020(01)00166-1

Reference yield:

: 2426-84-8
4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde

: 350249-72-8
ethyl-2,2-(3,3-diethoxypropyl)-6-methoxy-7-benzyloxyquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / ethanol / 2 h / Heating

2: 98 percent / sodium sulfide nonahydrate / ethanol / Heating

3: 77 percent / piperidine / ethanol / 24 h / Heating

With piperidine; sodium sulfide; In ethanol; 2: Zinin reduction / 3: Friedlander condensation;
DOI:10.1016/S0040-4020(01)00166-1

Reference yield:

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 350249-72-8
ethyl-2,2-(3,3-diethoxypropyl)-6-methoxy-7-benzyloxyquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / sodium iodide / acetone / 120 h / 20 °C

2.1: sodium hydride; n-butyllithium / tetrahydrofuran; hexane; various solvent(s) / 0.25 h

2.2: hexamethylphosphoramide / tetrahydrofuran; hexane; various solvent(s) / 0.33 h

2.3: 69 percent / tetrahydrofuran; hexane; various solvent(s) / 12 h / 20 °C

3.1: 77 percent / piperidine / ethanol / 24 h / Heating

With piperidine; n-butyllithium; sodium hydride; sodium iodide; In tetrahydrofuran; ethanol; hexane; acetone; 3.1: Friedlander condensation;
DOI:10.1016/S0040-4020(01)00166-1