4-[4-(6-aminopyrimidin-4-ylamino)-7-chloropyrazolo[4,3-c]pyridine-2-yl]-3,5-dichlorobenzonitrile

Base Information

Chemical Name:4-[4-(6-aminopyrimidin-4-ylamino)-7-chloropyrazolo[4,3-c]pyridine-2-yl]-3,5-dichlorobenzonitrile
CAS No.:1378038-44-8
Molecular Formula:C₁₇H₉Cl₃N₈
Molecular Weight:431.671
Hs Code.:

Synonyms:4-[4-(6-aminopyrimidin-4-ylamino)-7-chloropyrazolo[4,3-c]pyridine-2-yl]-3,5-dichlorobenzonitrile

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Chemical Property of 4-[4-(6-aminopyrimidin-4-ylamino)-7-chloropyrazolo[4,3-c]pyridine-2-yl]-3,5-dichlorobenzonitrile

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Technology Process of 4-[4-(6-aminopyrimidin-4-ylamino)-7-chloropyrazolo[4,3-c]pyridine-2-yl]-3,5-dichlorobenzonitrile

There total 9 articles about 4-[4-(6-aminopyrimidin-4-ylamino)-7-chloropyrazolo[4,3-c]pyridine-2-yl]-3,5-dichlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1378040-12-0
{6-[7-chloro-2-(2,6-dichloro-4-cyanophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

: 1378038-44-8
4-[4-(6-aminopyrimidin-4-ylamino)-7-chloropyrazolo[4,3-c]pyridine-2-yl]-3,5-dichlorobenzonitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 50 ℃; for 18h;

Reference yield:

: 1009334-04-6
4,5-dichloropyridine-3-carbaldehyde

: 1378038-44-8
4-[4-(6-aminopyrimidin-4-ylamino)-7-chloropyrazolo[4,3-c]pyridine-2-yl]-3,5-dichlorobenzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: triethylamine; titanium tetrachloride / dichloromethane / 1 h / 0 - 20 °C / Reduced presure

3.1: toluene / 18 h / 20 °C / Reflux

4.1: dihydrogen peroxide; methyltrioxorhenium(VII) / dichloromethane / 68 h / 20 °C

4.2: 1 h

5.1: trichlorophosphate / 1,2-dichloro-ethane / 2.3 h / 20 - 70 °C

6.1: trimethylsilyl bromide / propiononitrile / 4 h / Reflux

7.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 70 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 18 h / 50 °C

With hydrogenchloride; sodium azide; trimethylsilyl bromide; dihydrogen peroxide; titanium tetrachloride; methyltrioxorhenium(VII); caesium carbonate; triethylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; propiononitrile;

Reference yield:

: 55934-00-4
3,4-dichloropyridine

: 1378038-44-8
4-[4-(6-aminopyrimidin-4-ylamino)-7-chloropyrazolo[4,3-c]pyridine-2-yl]-3,5-dichlorobenzonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3.8 h / -78 - -30 °C

1.2: 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: triethylamine; titanium tetrachloride / dichloromethane / 1 h / 0 - 20 °C / Reduced presure

4.1: toluene / 18 h / 20 °C / Reflux

5.1: dihydrogen peroxide; methyltrioxorhenium(VII) / dichloromethane / 68 h / 20 °C

5.2: 1 h

6.1: trichlorophosphate / 1,2-dichloro-ethane / 2.3 h / 20 - 70 °C

7.1: trimethylsilyl bromide / propiononitrile / 4 h / Reflux

8.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 70 °C / Inert atmosphere

9.1: hydrogenchloride / 1,4-dioxane / 18 h / 50 °C

With hydrogenchloride; n-butyllithium; sodium azide; trimethylsilyl bromide; dihydrogen peroxide; titanium tetrachloride; methyltrioxorhenium(VII); caesium carbonate; triethylamine; diisopropylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; propiononitrile;