Technology Process of trans-8-(benzyloxy)-9-methoxy-1,2,3,4,4a,5,6,10b-octahydrobenzoquinoline
There total 7 articles about trans-8-(benzyloxy)-9-methoxy-1,2,3,4,4a,5,6,10b-octahydrobenzoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; acetic acid;
In
1,4-dioxane;
DOI:10.1055/s-1986-31687
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) triethylsilane, 2.) trifluoroacetic acid / 1.) CH2Cl2, room temp., 10 min, 2.) room temp., 20 h
2: 46 percent / NaBH4, glacial acetic acid / dioxane
With
triethylsilane; sodium tetrahydroborate; acetic acid; trifluoroacetic acid;
In
1,4-dioxane;
DOI:10.1055/s-1986-31687
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / K2CO3 / ethanol / 5 h / Heating
2: 65 percent / t-BuOK / diethyl ether / 0.75 h / 25 °C
3: 1.) Tl(NO3)3, 2.) 10percent HCl / 1.) MeOH, 1 min, 2.) 20 h
4: 1.) pyrrolidine, p-toluenesulfonic acid / 1.) benzene, reflux, 3 h, 2.) a) 80 deg C, 3 h, b) 130 deg C, 30 min
5: 33 percent / Et3SiH, CF3COOH / CH2Cl2 / 20 h / Ambient temperature
6: NaBH4, AcOH / dioxane / 7 h / Heating
With
pyrrolidine; hydrogenchloride; triethylsilane; sodium tetrahydroborate; potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; thallium(III) nitrate;
In
1,4-dioxane; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm00169a031
