Methyl 4-(acetylamino)-3-amino-5-chloro-2-methoxybenzoate

Base Information

Chemical Name:Methyl 4-(acetylamino)-3-amino-5-chloro-2-methoxybenzoate
CAS No.:126463-86-3
Molecular Formula:C₁₁H₁₃ClN₂O₄
Molecular Weight:272.688
Hs Code.:
DSSTox Substance ID:DTXSID401196367

Synonyms:methyl 4-(acetylamino)-3-amino-5-chloro-2-methoxybenzoate;126463-86-3;SCHEMBL4256804;VTECMRKKYXWWIS-UHFFFAOYSA-N;DTXSID401196367

Suppliers and Price of Methyl 4-(acetylamino)-3-amino-5-chloro-2-methoxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 4-(acetylamino)-3-amino-5-chloro-2-methoxybenzoate

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:272.0563846
Heavy Atom Count:18
Complexity:326

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)NC1=C(C=C(C(=C1N)OC)C(=O)OC)Cl

Technology Process of Methyl 4-(acetylamino)-3-amino-5-chloro-2-methoxybenzoate

There total 2 articles about Methyl 4-(acetylamino)-3-amino-5-chloro-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 126463-85-2
4-acetylamino-5-chloro-2-methoxy-3-nitro-benzoic acid methyl ester

: 126463-86-3
methyl 4-acetylamino-3-amino-5-chloro-2-methoxybenzoate

Guidance literature:: With hydrogen; nickel; In ethanol; water; at 20 ℃; for 1h; under 3344 Torr;
DOI:10.1248/cpb.50.941

Reference yield:

: 4093-31-6
methyl 2-methoxy 4-acetamido 5-chloro benzoate

: 126463-86-3
methyl 4-acetylamino-3-amino-5-chloro-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / conc. H₂SO₄; fuming HNO₃ / 0.08 h / 10 °C

2: 96 percent / H₂ / Raney-Ni / ethanol; H₂O / 1 h / 20 °C / 3344 Torr

With sulfuric acid; hydrogen; nitric acid; nickel; In ethanol; water;
DOI:10.1248/cpb.50.941