N-(1-NAPHTHYL) ACRYLAMIDE

Base Information

• Chemical Name: N-(1-NAPHTHYL) ACRYLAMIDE
• CAS No.: 22302-62-1
• Molecular Formula: C13H11 N O
• Molecular Weight: 197.23
• Hs Code.: 2924299090
• Mol file: 22302-62-1.mol

Synonyms:Acrylamide,N-1-naphthyl- (8CI); N-(1-Naphthalenyl)acrylamide

Chemical Property of N-(1-NAPHTHYL) ACRYLAMIDE

Chemical Property:

• Melting Point: 138-139°C
• PSA: 29.10000
• LogP: 3.03730

Purity/Quality:

97% ^*data from raw suppliers

N-(1-NAPHTHYL)ACRYLAMIDE 98.00% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(1-NAPHTHYL) ACRYLAMIDE

There total 2 articles about N-(1-NAPHTHYL) ACRYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

1-amino-naphthalene (134-32-7) + acryloyl chloride (814-68-6,25189-84-8) → N-α-naphthyl acrylamide (22302-62-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.chembiol.2019.03.016

Reference yield:

→ N-α-naphthyl acrylamide (22302-62-1)

Guidance literature:

With sodium hydroxide;

Reference yield: 73.0%

N-α-naphthyl acrylamide (22302-62-1) + 3-nitro-benzaldehyde (99-61-6) → N-α-naphthyl-3-hydroxy-2-methylene-3-(3-nitrophenyl) propionamide

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; for 192h;

DOI:10.1081/SCC-200054850

upstream raw materials:

1-amino-naphthalene

acryloyl chloride

Downstream raw materials:

3,3-bis(4-methoxyphenyl)-N-(naphthalen-1-yl)acrylamide

Refernces

• 1、 Berdan, Charles A.,Ho, Raymond,Lehtola, Haley S.,To, Milton,Hu, Xirui,Huffman, Tucker R.,Petri, Yana,Altobelli, Chad R.,Demeulenaere, Sasha G.,Olzmann, James A.,Maimone, Thomas J.,Nomura, Daniel K.. "Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells". . p. 1027 - 22,1035. Retrieved 2019/07/17.
• 2、 Wang, Hua,Guo, Li-Na,Duan, Xin-Hua. "Metal-free oxidative spirocyclization of hydroxymethylacrylamide with 1,3-dicarbonyl compounds: A new route to spirooxindoles". supporting information. p. 5254 - 5257. Retrieved 2013/11/06.