ethyl 1-(1,4-dioxepan-6-yl)-5-[4-(2-methoxy-3,5-dimethylpyridin-4-yl)-2-nitrophenyl]-1H-pyrazole-4-carboxylate

Base Information

Chemical Name:ethyl 1-(1,4-dioxepan-6-yl)-5-[4-(2-methoxy-3,5-dimethylpyridin-4-yl)-2-nitrophenyl]-1H-pyrazole-4-carboxylate
CAS No.:1449783-46-3
Molecular Formula:C₂₅H₂₈N₄O₇
Molecular Weight:496.52
Hs Code.:

Synonyms:ethyl 1-(1,4-dioxepan-6-yl)-5-[4-(2-methoxy-3,5-dimethylpyridin-4-yl)-2-nitrophenyl]-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 1-(1,4-dioxepan-6-yl)-5-[4-(2-methoxy-3,5-dimethylpyridin-4-yl)-2-nitrophenyl]-1H-pyrazole-4-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 1-(1,4-dioxepan-6-yl)-5-[4-(2-methoxy-3,5-dimethylpyridin-4-yl)-2-nitrophenyl]-1H-pyrazole-4-carboxylate

There total 8 articles about ethyl 1-(1,4-dioxepan-6-yl)-5-[4-(2-methoxy-3,5-dimethylpyridin-4-yl)-2-nitrophenyl]-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429510-40-6
ethyl 5-(4-bromo-2-nitrophenyl)-1-(1,4-dioxepan-6-yl)-1H-pyrazole-4-carboxylate

: 1429510-64-4
(2-methoxy-3,5-dimethylpyridin-4-yl)boronic acid

: 1449783-46-3
ethyl 1-(1,4-dioxepan-6-yl)-5-[4-(2-methoxy-3,5-dimethylpyridin-4-yl)-2-nitrophenyl]-1H-pyrazole-4-carboxylate

Guidance literature:: ethyl 5-(4-bromo-2-nitrophenyl)-1-(1,4-dioxepan-6-yl)-1H-pyrazole-4-carboxylate; (2-methoxy-3,5-dimethylpyridin-4-yl)boronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 6.75h;

(2-methoxy-3,5-dimethylpyridin-4-yl)boronic acid; In 1,4-dioxane; water; at 100 ℃; for 2.5h;

Reference yield:

: 153034-78-7
2-Fluoro-3-iodo-5-methylpyridine

: 1449783-46-3
ethyl 1-(1,4-dioxepan-6-yl)-5-[4-(2-methoxy-3,5-dimethylpyridin-4-yl)-2-nitrophenyl]-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1.5 h / -74 - -72 °C

1.2: 2 h / -74 - -70 °C

2.1: tetrahydrofuran; methanol / 2 h / 55 - 65 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 1.58 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 6.75 h / 100 °C

4.2: 2.5 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; caesium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;

Reference yield:

: 2369-19-9
2-fluoro-5-methylpyridine

: 1449783-46-3
ethyl 1-(1,4-dioxepan-6-yl)-5-[4-(2-methoxy-3,5-dimethylpyridin-4-yl)-2-nitrophenyl]-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 3.5 h / -75 °C

1.2: 1.92 h / -75 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1.5 h / -74 - -72 °C

2.2: 2 h / -74 - -70 °C

3.1: tetrahydrofuran; methanol / 2 h / 55 - 65 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: 1.58 h / 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,4-dioxane / 6.75 h / 100 °C

5.2: 2.5 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; caesium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;