4-Hydroxy-7-iodoquinoline

Base Information

• Chemical Name: 4-Hydroxy-7-iodoquinoline
• CAS No.: 22297-71-8
• Molecular Formula: C₉H₆INO
• Molecular Weight: 271.057
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID20496603
• Wikidata: Q82345578
• Mol file: 22297-71-8.mol

Synonyms:22297-71-8;4-Hydroxy-7-iodoquinoline;7-IODOQUINOLIN-4-OL;7-IODO-1H-QUINOLIN-4-ONE;7-iodo-4-hydroxyquinoline;7-Iodoquinolin-4(1H)-one;SCHEMBL8601956;DTXSID20496603;SB71147;FT-0649598

Chemical Property of 4-Hydroxy-7-iodoquinoline

Chemical Property:

• Vapor Pressure: 9.33E-07mmHg at 25°C
• Refractive Index: 1.768
• Boiling Point: 393.5°C at 760 mmHg
• Flash Point: 191.8°C
• PSA: 33.12000
• Density: 1.974g/cm³
• LogP: 2.54500
• Storage Temp.: 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 270.94941
• Heavy Atom Count: 12
• Complexity: 227

Purity/Quality:

98%min ^*data from raw suppliers

7-Iodoquinolin-4-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C1I)NC=CC2=O

Technology Process of 4-Hydroxy-7-iodoquinoline

There total 9 articles about 4-Hydroxy-7-iodoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-hydroxy-7-iodo-quinoline-3-carboxylic acid (22200-49-3) → 7-iodo-quinolin-4-ol (22297-71-8)

Guidance literature:

at 280 ℃; for 15h;

Reference yield: 94.0%

C10H6INO3 (1062589-61-0,22200-49-3) → 7-iodo-quinolin-4-ol (22297-71-8)

Guidance literature:

In diphenylether; for 0.333333 - 0.416667h; Heating / reflux;

Reference yield:

4-hydroxy-7-iodo-quinoline-3-carboxylic acid ethyl ester (22200-48-2) → 7-iodo-quinolin-4-ol (22297-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 N NaOH / Heating

2: diphenyl ether / 1 h / Heating

With sodium hydroxide; In diphenylether;

DOI:10.1021/jm980146x

upstream raw materials:

4-hydroxy-7-iodo-quinoline-3-carboxylic acid

4-hydroxy-7-iodo-quinoline-2-carboxylic acid

4-hydroxy-7-iodo-quinoline-3-carboxylic acid ethyl ester

diethyl 2-(((3-iodophenyl)amino)methylene)malonate

Downstream raw materials:

4-chloro-7-iodoquinoline

4-(3-Dimethylaminopropylamino)-7-iodchinolin

4-chloro-8-aminoquinoline

(1-benzyl-7-iodo-1H-quinolin-4-ylidene)-pentyl-amine