diethyl 1-(benzyloxycarbonylamino)-1-trifluoromethylbut-3-yne-1-ylphosphonate

Base Information

• Chemical Name: diethyl 1-(benzyloxycarbonylamino)-1-trifluoromethylbut-3-yne-1-ylphosphonate
• CAS No.: 1228473-25-3
• Molecular Formula: C₁₇H₂₁F₃NO₅P
• Molecular Weight: 407.326
• Mol file: 1228473-25-3.mol

Synonyms:diethyl 1-(benzyloxycarbonylamino)-1-trifluoromethylbut-3-yne-1-ylphosphonate

Chemical Property of diethyl 1-(benzyloxycarbonylamino)-1-trifluoromethylbut-3-yne-1-ylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 1-(benzyloxycarbonylamino)-1-trifluoromethylbut-3-yne-1-ylphosphonate

There total 2 articles about diethyl 1-(benzyloxycarbonylamino)-1-trifluoromethylbut-3-yne-1-ylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

diethyl (N-benzyloxycarbonyl-2,2,2-trifluoroethaneimidoyl)phosphonate (296238-72-7) + allenylmagnesium bromide (18295-60-8) → diethyl 1-(benzyloxycarbonylamino)-1-trifluoromethylbut-3-yne-1-ylphosphonate (1228473-25-3)

Guidance literature:

diethyl (N-benzyloxycarbonyl-2,2,2-trifluoroethaneimidoyl)phosphonate; allenylmagnesium bromide; In diethyl ether; at -78 - 20 ℃; for 5h;

With ammonium chloride; In diethyl ether; water;

DOI:10.1016/j.jfluchem.2009.12.003

Reference yield:

diethyl (N-benzyloxycarbonyl-2,2,2-trifluoroethaneimidoyl)phosphonate (296238-72-7) + propargyl bromide (106-96-7) → diethyl 1-(benzyloxycarbonylamino)-1-trifluoromethylbut-3-yne-1-ylphosphonate (1228473-25-3)

Guidance literature:

With magnesium; In diethyl ether; at -78 ℃;

DOI:10.1002/ejoc.202100040

Reference yield: 92.0%

diethyl 1-(benzyloxycarbonylamino)-1-trifluoromethylbut-3-yne-1-ylphosphonate (1228473-25-3) + 1-azido-1H,1H,2H,2H-perfluorodecane (121177-79-5) → C27H25F20N4O5P (1233220-50-2)

Guidance literature:

With sodium ascorbate; copper(II) sulfate; In water; tert-butyl alcohol; at 80 ℃; for 2h;

DOI:10.1016/j.jfluchem.2009.12.003

upstream raw materials:

diethyl (N-benzyloxycarbonyl-2,2,2-trifluoroethaneimidoyl)phosphonate

allenylmagnesium bromide

propargyl bromide

Downstream raw materials:

C₂₇H₂₅F₂₀N₄O₅P

diethyl [1-{[(benzyloxy)carbonyl]amino}-2,2,2-trifluoro-1-({3-[4-(trifluoromethyl)phenyl]isoxazol-5-yl}methyl)ethyl]phosphonate

diethyl (1-{[(benzyloxy)carbonyl]amino}-2,2,2-trifluoro-1-{[3-(4-nitrophenyl)isoxazol-5-yl]methyl}ethyl)phosphonate