isopropyl alpha-p-methylphenyldiazoacetate

Base Information

Chemical Name:isopropyl alpha-p-methylphenyldiazoacetate
CAS No.:1432320-26-7
Molecular Formula:C₁₂H₁₄N₂O₂
Molecular Weight:218.255
Hs Code.:

Synonyms:isopropyl alpha-p-methylphenyldiazoacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of isopropyl alpha-p-methylphenyldiazoacetate

Chemical Property:

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Technology Process of isopropyl alpha-p-methylphenyldiazoacetate

There total 3 articles about isopropyl alpha-p-methylphenyldiazoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 622-47-9
4-tolylacetic acid

: 67-63-0,8013-70-5
isopropyl alcohol

: 1432320-26-7
isopropyl alpha-p-methylphenyldiazoacetate

Guidance literature:: 4-tolylacetic acid; isopropyl alcohol; With sulfuric acid; at 90 ℃; for 12h;

With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 12h;
DOI:10.1002/anie.201608937

Reference yield:

: 64450-64-2
isopropyl 2-p-tolylacetate

: 1432320-26-7
isopropyl alpha-p-methylphenyldiazoacetate

Guidance literature:: With 4-toluenesulfonyl azide; In acetonitrile;
DOI:10.1002/adsc.201801389 DOI:10.1002/adsc.201801389

Reference yield:

: 622-47-9
4-tolylacetic acid

: 1432320-26-7
isopropyl alpha-p-methylphenyldiazoacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 23 °C / Inert atmosphere

With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;
DOI:10.1039/d1cc06945d