(3R,4R)-3,4-di(triethylsiloxy)-6-(4-methoxyphenylmethyloxy)-3-methyl-1-hexyne

Base Information

• Chemical Name: (3R,4R)-3,4-di(triethylsiloxy)-6-(4-methoxyphenylmethyloxy)-3-methyl-1-hexyne
• CAS No.: 1016985-78-6
• Molecular Formula: C₂₇H₄₈O₄Si₂
• Molecular Weight: 492.847
• Mol file: 1016985-78-6.mol

Synonyms:(3R,4R)-3,4-di(triethylsiloxy)-6-(4-methoxyphenylmethyloxy)-3-methyl-1-hexyne

Chemical Property of (3R,4R)-3,4-di(triethylsiloxy)-6-(4-methoxyphenylmethyloxy)-3-methyl-1-hexyne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4R)-3,4-di(triethylsiloxy)-6-(4-methoxyphenylmethyloxy)-3-methyl-1-hexyne

There total 1 articles about (3R,4R)-3,4-di(triethylsiloxy)-6-(4-methoxyphenylmethyloxy)-3-methyl-1-hexyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(3R,4R)-6-(4-methoxyphenylmethyloxy)-3-methyl-1-hexyne-3,4-diol (1016985-77-5) + triethylsilyl trifluoromethyl sulfonate (79271-56-0) → (3R,4R)-3,4-di(triethylsiloxy)-6-(4-methoxyphenylmethyloxy)-3-methyl-1-hexyne (1016985-78-6)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1021/ol800195g DOI:10.1002/chem.201000795

Reference yield: 87.0%

(3R,4R)-3,4-di(triethylsiloxy)-6-(4-methoxyphenylmethyloxy)-3-methyl-1-hexyne (1016985-78-6) + methyl chloroformate (79-22-1) → (4R,5R)-methyl 4,5-di(triethylsiloxy)-7-(4-methoxyphenylmethyloxy)-4-methyl-2-heptynoate (1016985-79-7)

Guidance literature:

(3R,4R)-3,4-di(triethylsiloxy)-6-(4-methoxyphenylmethyloxy)-3-methyl-1-hexyne; With n-butyllithium; In tetrahydrofuran; hexane; at -50 - -40 ℃;

methyl chloroformate; In tetrahydrofuran; hexane; at -40 ℃; for 1h;

DOI:10.1021/ol800195g DOI:10.1002/chem.201000795

upstream raw materials:

(3R,4R)-6-(4-methoxyphenylmethyloxy)-3-methyl-1-hexyne-3,4-diol

triethylsilyl trifluoromethyl sulfonate

Downstream raw materials:

(4R,5R)-methyl 4,5-di(triethylsiloxy)-7-(4-methoxyphenylmethyloxy)-4-methyl-2-heptynoate